What (7) agents are nucleoside/tide reverse transcriptase inhibitors? (NRTIs)
What are class adverse effects of NRTIs?
Which NRTI is a synthetic guanosine analog?
Which agent is associated with HLA-B*5701?
Which agent is associated with a hypersensitivity run (fever, abdominal pain, GI complaints)
Which agent is associated with an increased half life when taken with large doses of ethanol?
Which two NRTI's should not be used together?
Which two agents are cytidine analogues active against HIV-1, HIV-2, and HBV?
Which two NRTIs have low affinity for DNA therefore low toxicities?
Hyperpigmentation of the skin, especially in sun-exposed areas
Which NRTI has high levels of resistance with M184V and M184I?
Which NRTI is a derivative of 5-AMP that lacks a complete ribose ring?
Which NRTI is the only nucleotide analogue on the market?
Which NRTI is used for HIV pre-exposure prophylaxis?
Which NRTI is associated with Fanconi syndrome (excessive amount of phosphorus, glucose, protein, and uric acid in the urine)?
ADE's of Tenofovir?
1. Fanconi syndrome
3. Decreased BMD
Which version of Tenofovir is rapidly hydrolyzed to the active form?
Which version of Tenofovir is taken up into t-cells and then is converted to tenofovir?
Which version of tenofovir is associated with lower levels of circulating TFV?
Which NRTI is used to prevent congenital transfer of HIV?
ADEs of Zidovudine:
Bone marrow suppression (anemia, leukopenia)
ADEs of Stavudine?
Progressive motor neuropathy- Guillian-Barre syndrome
Which NRTI is acid labile and administered with an antacid buffer?
ADEs of Didanosine
Pancreatitis (mitochondrial toxicity)
Which class of agents bind to the hydrophobic pocket in the p66 unit of the HIV-1 reverse transcriptase?
NNRTI's are active against HIV-1/ other retroviruses? T/F
NNRTI's have activity against host cell DNA polymerases?
Bioavailability increased with high-fat meal
Poor CNS penetration
Should be taken at bedtime on an empty stomach
Which NNRT is associated with dysphoris/vivid dreams/ insomnia?
Which NNRTI is associated with QTc prolongation?
Which NNRTI is associated with rash/ SJS?
Which NNRTI has the best side effect profile?
Rilpivirine retains activity against efavirenz resistant strains? T/F
Higher concentrations of which NNRTI is associated with QTc prolongation?
Which agent should be used if baseline VL >100,000 or CD4 <200
Which NNRTI has a pH dependent absorption?
Which NNRTI is associated with rash/ SJS/ TENS?
Severe/fatal hepatitis has been reported with which NNRTI?
Which class of agents are associated with cardiac conduction abnormalities, bleeding in hemophiliacs, and lipid accumulation?
Which PI is available for pediatric patients?
Which PI has sulfa and may cause a rash?
ADEs of Darunavir
Which PI is pH dependent?
Atazanavir (better lipid profile)
Which PI may cause kidney stones?
Which PI is also a potent CYP3A4 inhibitor?
Higher doses of ritonavir lead to intolerability? T/F
Two unique ADEs of ritonavir?
Taste perversion (dose dependent)
Elevations in serum cholesterol and TG's
Which PI is associated with cystalluria and nephrolithiasis due to poor drug solubility?
- Need to drink 2L of water daily
COBI is a more potent and selective inhibitor of 3A4? T/F
Which class of agents prevent covalent bonding between host and viral DNA by interfering with divalent cations in enzymes catalytic core?
Integrase inhibitors produce a more rapid decline in plasma viral RNA over the first 3-4 months of therapy than other antiretrovirals and are overall better tolerated?
Which II AUC will be increased with a high fat meal?
High fat meal would be associated with:
Which two II's are eliminated by UGT1A1?
Two DDI with Raltegravir?
Which II is associated with elevations in CPK and has a risk of rhabomyolysis
Which agent shares cross resistance with mutations that affect raltegravir?
Elvitegravir is co-formulated with a 4 drug combination with COBI?
Elvitegravir is eliminated by CYP3A4?
Which II retains activity against viruses that have become resistant to RAL and EVG?
Which II is a one pill, once daily regimen?
Which II has a high barrier to resistance like Dolutegravir but is available as a combination agent?
Which agent is a part of the smallest combo pill on the market?
Which II is available IM?
How often in Im Cabotegravir dosed?
IM Cabenuva requires a two month lead in with oral dose?
False- one month
What are the two DDI's of Cabotegravir that are mitigated with the IM formula?
Pruitis at injection site
Which entry inhibitor can only be used in HIV-infected adults who have baseline evidence of predominately CCR5-tropic virus?
Which agent retains activity against viruses that have become resistant to other agents due to MOA?
Cough, fever URTI
How is Fuzeon administered?
ADEs of Fuzeon?
HIGH RATE OF LOCAL INJECTION SITE RXNS
Which agent is indicated to be used in conjunction with other antiretrovirals in treatment experiences patients with MDR infections currently failing therapy?
- 2000 mg IV LD, followed by 800 mg IV MD
Which agent is approved for use in HIV-infected adults with heavy treatment experience and multi drug resistant HIV-1 infection currently failing treatment?
- 600 mg PO BID
Fostemsavir is a prodrug?
ADEs of Fostemsavir: