Gastric Decontamination Flashcards


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created 1 year ago by taniaharper
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Dr. Lopez
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1

Common toxins- when given in high doses

analgesics, cleaning products, cosmetics/personal care, antidepressants, antihistamines

2

Three antihypertensives that kill

clonidine, guanfacine, CCB

3

MOA of clonidine

selective alpha2 adrenergic receptor agonist

  • developed as nasal decongestant

4

Clinical effects of clonidine toxicity

constricted pupils, hypothermia, bradycardia, CNS and respiratory depression, apnea, hypotension

5

MOA guanfacine

alpha 2 adrenergic receptor agonist

6

Effects of CCBs toxicity

lethargy, hypotension, bradycardia, AV block, asystole, reflex tachycardia, hyperglycemia, illeus, bowel ischemia

7

MOA of CCB

  • binds L-type Ca+ channels
  • relax vascular smooth muscle
  • arterial vasodilation, decreased force of contraction, decrease HR and conduction

8

Mild hypoglycemia side effects (<60 mg/dL)

tremor, diaphoresis, tachy, nausea, drowsy

9

Severe hypoglycemia side effects

delirium, coma, seizures, dysrhythmias-PVCs, sinus tachycardia, afib

10

MOA of imidazole decongestants

stimulates peripheral alpha 2 receptors

(in OD it also stimulates central alpha 2 receptors)

11

Names of some imidazoline decongestants

tetrahydrozoline, oxymetazoline, naphazoline, xylometazoline

12

Effects of imidazoline decongestants mild toxicity

tachycardia, hypertension, agitation, diaphoresis, cyanosis, ataxia

13

Effects of imidazoline decongestants severe toxicity

lethargy, bradycardia, hypotension, respiratory depression, apnea, hypothermia

14

Onset of Camphor

5min to 1 hr

15

Effects of camphor toxicity

vomit, confusion, agitation, tachycardia, hyperreflexia, cyanosis, seizures

**1 mouthful is enough to cause seizures**

16

effects of first generation TCAs toxicity

death with 15 mg/kg, rhythm changes, conduction delays, hypotension, seizures

17

Effects of antimalarial (chloroquine, hydroxychloroquine) toxicity

hypotension, QRS/QTc prolongation, dyspnea, drowsiness, hypokalemia, apnea, seizures

18

Effects of antidiarrheal (lomotil) toxicity

coma, respiratory depression, anticholinergic

19

Toxic alcohols

ethylene glycol (radiator fluid)and methanol (windshield wiper fluid)

**parent compound is not toxic, what it is converted to is toxic**

20

Ethylene glycol targets what organ

kidneys

21

Methanol targets what organ

Eyes (4 mls can cause permanent blindness)

22

Treatment for ethylene glycol

Fomepizole (inhibits alcohol dehydrogenase)

23

Methyl salicylate has what medication in it that causes toxicity

aspirin

(1 mouthful= 7 grams of aspirin)