1/17 Molecular Flashcards


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1

cause of muscular dystrophy diseases

mutation in the dystrophin gene, causing a shock absorber protein not to be produced or to be produced incorrectly

2

amphipathic

has both hydrophobic and hydrophilic parts

3

what kind of movement lipid bilayers can do, which makes them behave like a liquid

lipids and proteins in the bilayer are free to rotate and move laterally

4

what membrane fluidity depends on

phospholipid composition (saturated vs unsaturated), tail/chain length, amount of cholesterol

5

cell cortex

meshwork of protein that gives shape to and reinforces the cell membrane - well known for its role in giving RBCs their biconcave shape

6

where new membrane phospholipids are made

endoplasmic reticulum

7

scramblase

randomly flips phospholipids across the bilayer

8

3 places in the cell where new membrane phospholipids can go

stay in the ER, go to the cell's plasma membrane, go to another organelle in the cell

9

flippase

uses ATP to move phospholipids between layers - purposeful

10

by weight, ratio of lipids to proteins in most membranes

1:1

11

types of membrane proteins

transmembrane, monolayer associated, lipid linked, peripheral

12

monolayer associated

mostly in the cytosol

13

lipid linked

only attached to the membrane by a lipid group

14

peripheral

connected to the membrane by another protein

15

example of membrane domains tethered to other cells

tight junctions

16

examples of proteins with sugars attached

glycoproteins, proteoglycans, glycocalyx

17

AON

antisense oligonucleotides, used to block regions from being spliced or translated

18

type of mutation duchenne muscular dystrophy is associated with

frameshift mutation

19

how therapeutic drugs are attempting to treat Duchenne muscular dystrophy

causing a larger deletion of the DNA transcripts, leading to a less severe form of muscular dystrophy