1/17 immunology Flashcards


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1

makeup of the complement system

plasma proteins

2

what organ makes plasma proteins?

the liver

3

zymogens

inactive form of protease, requires cleavage by another protease to become active

4

3 paths of complement system to get rid of pathogen

lectin pathway, classical pathway, alternative pathway

5

what all three pathways converge to generate

C3 convertase

6

what happens to people with C3b problems

recurrent infections

7

what C3b does to a pathogen

attachment/bonding, opsonization

8

PAMPs

pathogen associated molecular patterns

9

C-type lectin

group of carbohydrate binding proteins, require calcium for binding

10

C3 convertase

C4b2a

11

necessary step for lectin, classical, and alternative pathways to continue

C protein cleavage

12

MASP

Mannan binding lectin associated serine protease (cleaving function)

13

3 effects of complement once it is activated

inflammatory cells are recruited, opsonization, perforation of pathogen membrane

14

alternative to C3 convertase

C3bBb

15

fluid phase C3 convertase

C3(H2O)Bb

16

anaphylatoxins

can induce anaphylactic shock

17

inflammatory response complement effect

increased fluid escape from the blood vessels, easier pathway for macrophages, neutrophils, lymphocytes to find and destroy pathogens

18

MAC

membrane attack complex

19

MAC's three main functions

loosen cellular homeostasis, disrupt proton gradient, form pathway for enzymes like lysozymes