Which two variants had increased severity?
Alpha and Delta
Which variant has increased transmissibility and immune evasion?
Risk factors for severe disease and death:
Mental health disorder
Substance used disorders
Amount of time from exposure to symptom onset?
About 10 days
S/sx of CV19 with NO dyspnea or abnormal lab imaging
Evidence of disease: but SpO2 >94%
What are the gold standard diagnostic tests for CV19 that have increased sensitivity and specificity?
What are the mRNA vaccines?
Moderna- 2nd dose 4-8 weeks later
Pfizer: 2nd dose 3-8 weeks later
Only nanoparticle vaccine?
When can a booster dose be administered?
At lease 2 months after 2nd primary series
What is the active component of Paxlovid?
Ritonavir is a CYP3A4 inhibitor
ADEs of Paxlovid?
Dosing of Paxlovid
300 mg Nirmatrelvir/ 150 mg ritonavir
PO BID x 5 days
What drug is a prodrug of adenosine triphosphate and causes viral chain termination?
What drug can cause accumulation of cyclodextrin vehicle in renal dysfunction?
Within how many days of symptom onset should remdesivir be given?
remdesivir outpatient dosing?
200 mg IV x 1 100 mg IV x 2
3 day course
remdesivir inpatient dosing?
200 mg IV x 1 100 mg IV x 4
What drug acts by "viral lethal mutagenesis" and "viral error catastrophe"
Treatment for hospitalized patients on conventional oxygen?
1. Minimal O2- remdesivir
2. Most patients- remdesivir and dexamethasone 6mg IV/PO
3. Increasing O2 needs- Add tocilizumab or barticitinib
What is the duration of dexamethasone therapy in severe CV19?
Treatment for hospitalized patients on HFNC or NIV
Dexamethasone + tocilizumab or barticitinib
Dexamethasone can be used in non-ventilated patients?
Which drug is an IL-6 inhibitor?
Which drug is a JAK inhibitor?