CV19 Flashcards


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created 1 year ago by abedfordpowell
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1

Which two variants had increased severity?

Alpha and Delta

2

Which variant has increased transmissibility and immune evasion?

Omnicron

3

Risk factors for severe disease and death:

Asthma

Cancer

DM

CVD

CKD

DM

HTN

Obesity

HIV

Mental health disorder

Pregnancy

Smoking

Substance used disorders

4

Amount of time from exposure to symptom onset?

5 days

5

Viral replication

About 10 days

6

Mild COVID

S/sx of CV19 with NO dyspnea or abnormal lab imaging

7

Moderate COVID

Evidence of disease: but SpO2 >94%

8

Severe COVID

SpO2 <94%

9

Critical COVID

Mechanical ventilation

10

What are the gold standard diagnostic tests for CV19 that have increased sensitivity and specificity?

NAAT

RT-PCR

11

What are the mRNA vaccines?

Moderna- 2nd dose 4-8 weeks later

Pfizer: 2nd dose 3-8 weeks later

12

Only nanoparticle vaccine?

Novavax

13

When can a booster dose be administered?

At lease 2 months after 2nd primary series

14

What is the active component of Paxlovid?

Nirmatrelvir

Ritonavir is a CYP3A4 inhibitor

15

ADEs of Paxlovid?

Transaminitis

Hepatotoxicity

HIV resistance

Dysgeusia

Diarrhea

Myalgia

HTN

16

Dosing of Paxlovid

300 mg Nirmatrelvir/ 150 mg ritonavir

PO BID x 5 days

17

What drug is a prodrug of adenosine triphosphate and causes viral chain termination?

Remdesivir

18

What drug can cause accumulation of cyclodextrin vehicle in renal dysfunction?

Remdesivir

19

Within how many days of symptom onset should remdesivir be given?

7-10 days

20

remdesivir outpatient dosing?

200 mg IV x 1 100 mg IV x 2

3 day course

21

remdesivir inpatient dosing?

200 mg IV x 1 100 mg IV x 4

22

What drug acts by "viral lethal mutagenesis" and "viral error catastrophe"

Molnupiravir

23

Treatment for hospitalized patients on conventional oxygen?

1. Minimal O2- remdesivir

2. Most patients- remdesivir and dexamethasone 6mg IV/PO

3. Increasing O2 needs- Add tocilizumab or barticitinib

24

What is the duration of dexamethasone therapy in severe CV19?

10 days

25

Treatment for hospitalized patients on HFNC or NIV

Dexamethasone + tocilizumab or barticitinib

26

Dexamethasone can be used in non-ventilated patients?

False

27

Which drug is an IL-6 inhibitor?

Tocilizumab

28

Which drug is a JAK inhibitor?

Barticitinib