CNS Flashcards


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created 1 year ago by abedfordpowell
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1

Aminoglycosides are a treatment option in which patient population

<1 month

2

Which treatment population require 3 different treatment options?

>50 yr

3

Meningitis treatment <1 month:

Ampicillin- Listeria

2 g IV q4 hours

Plus

Cefotaxime or Aminoglycosides- gram negative

4

Meningitis treatment >50

Ampicillin

and

Vancomycin

15-20 mg/kg IV q 8-12

and

Cefotaxime/Ceftriaxone

5

Meningitis treatment for 1 month- 2yrs and 2-50 yrs old?

Vancomycin

and

Ceftriaxone

2 g IV q12

6

Meningitis:

Inflammation of neurologic sequelae

7

Triad of Meningitis:

Fever

Nuchal rigidity

Headache

8

Presentation of meningitis

Altered mental status

+ Brudzinski's sign

+ Kernig's sign

Purpuric petechial lesions

Arthalgias

9

Diagnosis of Meningitis:

Lumbar puncture od CSF fluid prior to starting antibiotics

10

What factors will be elevated in a CSF analysis in Meningitis?

WBC > 5

Proteins >50

11

What factors will be decreased in a CSF analysis in Meningitis?

Glucose <45

CSF/BG <50

12

What will be dominant in CSF analysis in Meningitis?

Neutrophils

13

What type of organism has good CNS penetration?

Small, lipophilic, lowly protein bound

14

Which meningococcal vaccines are NOT interchangeable?

Recombinant: Men-B

Bexsero

Trumenba

15

When should kids get a booster shot?

at 16 y.o

College

16

Which organism should be treated for 7-10 days?

N. meningitis and H. Influenzae

S: Pen G or ampicillin

R: 3rd gen ceph

17

Which organism should be treated for 10-14 days?

S. pneumoniae

S: Pen G or ampicillin

R: 3rd gen ceph

18

Which organism should be treated for 14-21 days?

MSSA: Nafcillin or oxacillin

MRSA: Vancomycin

Group B Strept: Pen G or ampicillin +/- gentamicin

19

Which organism should be treated for 21 days or more?

Listeria- ampicillin

Enterobacteriae- 3rd gen ceph

Pseudomonas- Cefepime, Ceftazidime, Tobramycin

20

What are the two conditions in which dexamethasone should be used?

1. Infants with H. influenza of S. pneumoniae

2. Adults with pneumococcal meningitis

21

When should dexamethasone be given?

BEFORE or with antibiotics

Dexamethasone 0.15 mg/kg IV q6 hrs

22

What di-therapy should be used in non-penetrating head traumas?

Vancomycin

and

Cetriaxone

23

What di-therapy should be used in penetrating head traumas, post-neurosurgery, and CSF shunt?

Vancomycin

and

Cefepime, Ceftazidime, Meropenem (pseudomonas coverage)