What is the D.O.C for Neisseria?
What gram - cocci causes acute otitis media and sinusitis
What gram - bacilli causes wound infections and pneumonia?
3 DOC for KPC producers?
What gram - bacilli causes complicated UTI's?
Citrobacter and enterobacter cloacae
What is the DOC for Citrobacter and enterobacter cloacae?
What gram - bacilli causes skin and soft tissue infections?
What is the DOC for shigella/salmonella?
Which organisms cause complicated UTIs?
Citrobacter and enterobacter cloacae
What is the DOC for acinetobacter baumanni?
Unasyn and carbapenems
Which non-enterobacteriaceae causes BSI in the immunocompromised?
What is the DOC for Stenotrophomonas?
Which two organisms can cause community acquired pneumonia?
What is the DOC for Haemophilus
Augmentin and amoxicillin
What is the DOC for pasteurella?
Which three organisms can cause diabetic foot infections?
B. fragilis, prevotella, and pseudomonas
What anaerobic gram - bacilli causes gynecologic infections and abscesses?
DOC for B. fragilis?
2. Penicillin/B-Lactamase inhibitors
What anaerobic gram - bacilli causes periodontal infections?
HECK YES is an acronym to represent organisms that produce what resistance?
What are the 2 DOC for AmpC organisms?
Which three organisms cause ESBL resistance?
Klebsiella pneumoniae and oxytoca
What are the 2 DOC for ESBL organisms?
Cephalosporins: Cefoxitin and cefotetan
What is the only DOC for NDM?
Which three drugs cover CRE and not KPC?
Penicillin-B-lactamase inhibitor combination cover anaerobes? T/F
What BLI has activity against Acinetobacter baumannii?
What Gram - do Zosyn cover?
Acinetobacter/ Indole-positive proteus
Coverage of 2nd Gen Cephalosporins?
2nd Gen Cephalosporins
Cefuroxime- Ceftin (IM,IV,PO)
CI in neonates- kernicterus
Excellent BBB penetration
What is the DOC for penicillinase resistant strept pneumonia?
What 3rd generation cephalosporin has anti pseudomonal coverage?
What agent may cause encephalopathy and seizures?
What two agents are DOC for MDR pseudomonas?
DOC for MDR pseudomonas and KPC?
What is indication for Cefidericol?
Which class of agents have renal dose adjustments?
Carbapenems have anaerobic coverage? T/F
Which carbapenem has the highest seizure risk?
Which carbapenem is the most narrow spectrum and is dosed only once daily?
Ertapenem has poor activity against which organisms?
Carbapenems/BLI exhibit what coverage?
Recarbrio has MDR pseudomonas coverage? T/F
What drug should be used in the case of a documented type-1 hypersensitivity to a beta-lactam?
Azetronam has Gram + coverage? T/F
False- Gram - only!!
Aminoglycosides bind to which ribosome?
Which class of AB have mycobacterium?
What is the Peak to MIC ratio should be targeted with ahminoglycosides?
2 main ADE associated with Aminoglycosides?
Ototoxicity- may be irreversible
What type of amino glycoside dosing does NOT require peak and trough monitoring?
Extended interval dosing- once daily or less
Which class of AB's has atypical coverage against legionella pneumophila, mycoplasma pneumonia, chlamydophila pneumonia, MDR m. tuberculosis, non-tuberculous mycobacteria?
Fluroquinolones increase what?
Why should fluroquinolones be avoided in children <12, pregnancy, and breast feeding?
May impair cartilage development
What are the 8 ADEs associated with fluroquinolones?
1. GI distress
3. QTc prolongation
4. C. diff
7. Mental health side effects
What are the three indications where risks >> benefits with Fluroquinolones?
1. Acute sinusitis
3. Uncomplicated UTI
All Fluroquinolones are IV AND PO??
Which Fluroquinolone has the most pseudomonas coverage?
Which Fluroquinolone has the most pneumonia coverage?
Which Fluroquinolone has poor concentration in the urine and has anaerobic coverage?
Which Fluroquinolone has MRSA coverage?
Weight based dosing of Bactrim is based on which component?
DDI with Bactrim?
Bactrim should be avoided in the 1st and 3rd trimester of pregnancy?
What is DOC for stenotrophomonas?
What is DOC for
Which AB has a very LARGE Vd?
Which AB does not cover the three P's?
A 5 day course of Azithromycin is as efficacious as a 10-14 day treatment course?
Which class of AB is a major INHIBITOR of CYP3A4?
Which AB is the drug of choice for Legionella?
ADE's of Flagyl?
Disulfiram-like reaction with EtOH
Peripheral neuropathy with long term use
When should Flagyl be avoided
What is the DOC for bactericides fragilis?
What is DOC for trichomonad, giardiasis, and entamoeba?
Which ABs is used for cystitis only?
Which AB should be used with caution in 38-42 weeks gestation if G6PD deficiency due to concern for hemolytic anemia and neonatal jaundice?
What organisms due Nitrofurantoin cover?