lipid metabolism Flashcards


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created 2 weeks ago by Rereih
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1

lipoproteins classifications is based on

  • density
  • size
  • ratio of lipids to proteins

2

dyslipidemia is

elevation of plasma cholesterol

TGs

LDL levels that causes atherosclerosis

3

dyslipidemia causes

  1. primary genetic
  2. secondary

4

dyslipidemia diagnosis

  • lipid profile
  • plasma total cholesterol
  • TG
  • LDL
  • VLDL
  • HDL

5

primary hyperlipidemia causes

  • excessive production of TG LDL
  • defective clearance of TG LDL
  • under production of HDL
  • excessive clearance of HDL
  • Children

6

secondary hyperlipidemia causes

  • sedentary life style
  • excessive intake of saturated fat and cholesterol and trans
  • DM
  • CKD
  • hypothyroidism
  • cholestatic liver diseases
  • thiazide
  • b blockers
  • retinoids
  • antiretroviral agents
  • estrogen
  • progestin
  • glucocorticoids
  • adults

7

symptoms

  • symptomatic vascular disease (CAD, peripheral artery disease)
  • high TGs >acute pancreatitis, eruptive xanthomas
  • severely high TGs > lipemia retinalis
  • eyelids xanthelasma
  • arcus corneae
  • tendinous xanthelasma
  • extreme high lipids > milky blood plasma, paresthesia, dyspnea, confusion.

8

familiar hypercholesteremia

homozygous

cutaneous xanthomas

9

primary who is suspected

  • premature athrosclerotic disease
  • physical symptoms & fundus
  • family history
  • cholesterol >240 mg/dl
  • lipidprofile

10

labs for secondary

  • fasting glucose
  • liver enzymes
  • creatinine
  • TSH
  • urinary proteins

11

screening in adults >20

  • fasting lipid profile
  • every five years

12

screening in adults < 20

atherosclerotic risk factors

extensive family history (testing Lipoproteins a levels)

13

high LDL drug

  1. statins
  2. bile acid sequestrants
  3. ezetimibe

14

high TGs and low HDL drug

  1. niacin
  2. fibrates

15

drug for patients at risk of MI

low dose of aspirin