Focus on Nursing Pharmacology: Narcotic antagonists Flashcards


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chapter 26
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1

Narcotic antagonists names:

naloxone

naltrexone

2

What is naloxone used for

reversal of suspected acute narcotic overdose

Antidote: reversal of adverse effects of narcotics

3

what is naltrexone used for

orally for the management of alcoholism or narcotics dependency (addiction)

4

What is the mode of action for

naloxone

naltrexone

strongly bind to opioid receptor sites- (they do not activate the receptor)

they block the effects of the opioid receptor leading to the reversal of opioid

5

What are both naloxone naltrexone

used for?

Opioid overdose

reversal of adverse effects of narcotics

Tx narcotic and or alcoholism dependency

6

when are these drugs contraindicated for use?

used for life threatening situations no CI

just if have an allergy to them

7

Cautions:

pregnancy/ lactation

narcotic addiction (increased risk of withdrawals" abstinence syndrome"

CV Dz (blocks opioid receptors lead to sedation and depressing effects, all is reversed at same time)

8

adverse effects:

acute narcotic abstinence syndrome leads to withdrawal

symptoms of: tachycardia, BP changes, dysrhythmias

N/V

sweating

9

Drug/Drug:

large doses may be needed to reverse:

bup-ren-orphine

bu-tor-phanol

nal-buphine

penta-zocine

10

Important info:

maintain open airway

administer naloxone challenge before giving naltrexone

obtain ECG to detect any arrhythmias

continuous monitoring of respiratory, CNS, CV

11

What is a must before giving naltrexone

must be narcotic free 7-10days prior to administering to decrease acute withdrawal