The skin is considered as an _______ because of its extent and complexity
Organ
The two basic tissues of which skin is composed of are ____________ and ____________
Dense Irregular conn. and Stratified Squamos Epithelium
Dense Irregular Conn. makes up the ________
Dermis
Stratified Squamos Epithelium makes up the ________
Epidermis
The tough water- repellent protein found in the epidermal cells is called __________
Keratin
The pigments melanin and ___________ contribute to skin color.
Carotene
A localized concentration of melanin is called the ________.
Freckle
4 protective functions of the skin:
- Prevents ______
- Prevents _________ invasion
- Protects against _________ thermal
- Protects against _._ radiation
- Prevents desiccation
- Prevents bacterial invasion
- Protects against thermal damage
- Protects against U.V. radiation
Friction between Dermis and Epidermis results in ______.
Blisters
Immediately deep to the dermis is the __________ or _____________ (primarily adipose tissue)
Hypodermis or Superficial fascia
[not considered part of the skin.]
What layer of the skin is avascular?
Epidermis
Cells of Epidermis (4 types)
-
-
-
-
- Keratinocytes
- Melanocytes
- Langerhan's cells
- Merkel cells
The most abundant epidermis cells are _________.
Keratinocytes
The main function of Keratinocytes is to produce ___________ cell
Keratin
A protein that is fibrous and gives the epidermis its durability and protective capabilities
Keratin
Keratinocytes are tightly connected by _______________
Desmosomes
Describe the shape and color of melanocytes
Spidery black cells
Melanocytes produces the brown- to - black pigment called ____________.
Melanin
Why does the skin tan?
Melanin production increases when the skin is exposed to sunlight.
Melanin provides a protective pigment umbrella over the ____________________ in the deeper epidermis layers.
This protects the _._._.
Nuclei of the cell
D.N.A
Epidermal cells that play a role in immunity:
Langerhan's cells (A.K.A epidermal dendritic cells)
Merkel cells in conjunction with sensory nerve endings, form sensitive touch receptors called ________.
Merkel discs
Where are the Merkel Discs located?
epidermal dermal junction
Layers of the Epidermis
- Stratum _________
- Stratum _________
- Stratum _________
- Stratum _________
- Stratum _________
- Corneum (clear layer)
- Lucidum (horny layer)
- Granulosum (granular layer)
- Spinosum (spiny layer)
- Basale (basal layer)
The following are the characteristics of Epidermis layer:
- outer- most layer
- 20-30 cells
- dead and keratinized scalelike cells
- they are constantly rubbing off and replaced by divison of the deeper cells
Stratum Corneum
Epidermis layer:
- found only in the palms and soles
- not present i the regions of thin skin
- very thin translucent band of flattened dead keratinocytes
Stratum Lucidum
Epidermis layer:
- a layer named for the abundant granules its cells contain
- 2 types of these granules
- at the upper border of this layer, the cells begin to die.
Stratum granulum
The two types of granules are:
lamellated granules and keratohyaline granules
Define Lamellated Granules?
contain a waterproofing glycolipid that is secreted into the extracellular space
Define Keratohyaline Granules?
combine with the intermediate filaments in the more superficial layers to form the keratin fibrils.
Epidermis layer:
- its cells contain thick weblike bundles of intermediate filaments made of a pre- keratin protein
-apear spiky
Stratum Spinosum
Cells in the _________ layer and __________ layer are the only ones that receive adequete nourishment via diffusion of nutrients from the dermis
Spinosum and Basale
Epidermis layer:
- A single row of cells immediately adjacent to the dermis
- Cells are constantly undergoing mitotic cell div. to produce new cells
- alternative name is stratum germinativum
- 10% to 25% of the cells are melanocytes
Stratum Basale
The 2 principle regions of Dermis:
Papillary and Reticular
The more superficial dermal region
Papillary
papillary region is composed of _________ connective tissue
Areolar conn. tissue
Papillary region has finger like projections on its superior surface called ____________________. (which attaches to the epidermis above)
Dermal papillae
The dermal papillae produce _______________ on the palms and soles
Finger prints. (Unique pattern of epidermal ridges that stay the same)
Abundant capillary net work in the papillary layer provide _________ for the epidermis layer and allow ______ to radiate to the skin surface.
nutrients
heat
The touch and pain receptor _____________ are found here
Meissner's corpuscles
The deepest skin layer
Reticular layer
Reticular layers consists of:
- Arteries and Veins
- Sweat and Sebacceous gland
- Pacinian Corpuscles (pressure point)
Papillary and Reticular layers are heavily invested with ___________ and _____________ fibers.
Collagen and Elastic
Any sort of restriction of the normal blood supply to the skin result in _________ (cell death)
skin ulcer or bed sores
Some of the nerve ending receptors are:
- Meissner's Corpuscles (pain receptor)
- Pacinian Corpuscles (pressure receptor)
- Hair follicle receptor (root hair plexus)
Skin color is a result of:
-
-
-
- relative amount of melanin in skin
- relative amount of carotene in skin
- oxygenation of blood
______________ a yellow pigment.
Carotene
Carotene is primarily present in the stratum ____________ and ______________ tissue of hypodermis.
stratum corneum and adipose tissue
Skin color can be an important _________________.
diagnostic tool
Accessory organs of the skin:
- Cutaneous gland
- hair
- nails
Hair, nails, and cutaneous glands are all derivatives of ___________________ but they reside in _______.
Epidermis
Dermis
Hair consists of a ______________, a centralregion surrounded first by the __________ and then by a protective ___________.
medulla
central region surrounded by cortex and protective cuticle
Identity the parts of the hair:
- portion of hair enclosed within the follicle
- portion projecting from the scalp surface
- collection of well- nourished germinal epithelial cells at the basal end of the follicle
- root
- shaft
- hair bulb
A structure formed from both epidermal and dermal cells
Follicle
A small part of the dermal tissue protrudes into the hair bulb from the connective tissue sheath and provides nutrition to the growing hair is called the ____________-
Papilla
Small bands of smooth muscle cells connect each hair follicle to the papillary layer of the dermis.
Arrector pilli muscle
contraction of arrector pilli muscle results in
goose bumps
2 categories of cutaneous gland
sebacceous gland and sudoriferous gland
Sebacceous glands are found all over the body except for ______ and __________
palms and soles
product of sebacceous gland
sebum
accumulation of dried sebum, bacteria, and melanin from epitheloal cells in the oil duct
black head
an active infection of the sebacceous gland
acne
sweat glands are categorized by the composition of their _____________-
secretion
Merocrine sweat glands are also called the
Eccrine gland
Eccrine gland produces clear _____________ primarily made of water, salts and urea
perspiration
Apocrine glands are predominantly found in the ___________ and ___________ areas
axillary and genital area
Apocrine gland secrete a ____________________ substance that is excellent nutrient medium for microorganism found on the skin
milky protein and fat rich substance
Translucent cells in the thick skin containing keratin fibrils
stratum lucidum
dead cells
stratum corneum and lucidum
dermal layer responsible for fingerprints
papillary layer
vascular region
dermis-- papillary region, reticular
major skin area that produces derivatives
epidermis
apidermal region exhibiting the most rapid cell division
stratum basale
scalelike dead cells, full of keratin, that constantly slough off
stratum corneum
mitotic cells filled with intermediate filaments
stratum spinosum
has abundant elastic and collagenic fibers
dermis, reticular
location of melanocytes and merkel cells
stratum basale
area where weblike pre- keratin filaments first appear
stratum spinosum
region of areolar connective tissue
papillary layer
What substance is manufactured in the skin that plays a role in Ca+ absorption elsewhere in the body?
Vitamin D3




Eccerine gland.







A- Epidermis (Stratified Squamos Epithelium)
B- Dermis (pap- aerolar, retic.- Den Ireg.)
C- Hypodermis (Adipose)