Systemic Dimorphic Mycoses

Helpfulness: 0
Set Details Share
created 5 weeks ago by Pmborton
5 views
show moreless
Page to share:
Embed this setcancel
COPY
code changes based on your size selection
Size:
X
Show:
1

opportunistic

immunocompromised; many tissues, types of infections; ubiquitous

2

superficial

unsightly infections of the dead outer layers of hair and skin, no immune response

3

dermatophytes

infection is deeper than superficial, still dead outer layers, added immune response

4

subcutaneous

localized infection of muscle, bone, and connective tissues; traumatic inoculation

5

systemic

infects any tissue; true pathogens; geographically endemic; dimorphs and yeasts

6

serologic testing or biopsy

can detect most systemic infections

7

Blastomyces dermatitidis

cause of Gilchrist's disease; Mississippi river valley soil

8

Blastomyces dermatitidis

microscopic-mold fine, septate, hyaline hyphae; conidia directly on hyphae or on lateral conidiophores; yeast hyaline, large cells with budding

9

Blastomyces dermatitidis

at 25 C mold grows slowly on SDA, white to beige waxy colony; at 37 C yeast appears after 10-15 days on enriched media

10

Blastomyces dermatitidis mold phase

card image
11

Blastomyces dermatitidis yeast phase

card image
12

Coccidioides immitis/posadasii

cause of Valley Fever; hot, semi-arid climates-SW US and N Mexico

13

Coccidioides immitis/posadasii

microscopic: septate hyaline hyphae; arthroconidia-barrel shaped; disjuncture cells

14

Coccidioides immitis/posadasii

macroscopic: 3-5 days on SDA/SABHI; arthroconidia in 1-2 weeks; colonies white and cottony cobwebs; yeast grows in tissues but not found in lab

15

Coccidioides immitis/posadasii

card image
16

Histoplasma capsulatum

cause of Spelunker's disease; Mississippi/Ohio river valleys; soil with high nitrogen content

17

Histoplasma capsulatum

microscopic: fine septate hyphae, micro/macroconidia; tuberculative macroconidia at 25-30 C, yeast cells bud at narrow neck at 37 C

18

Histoplasma capsulatum

macroscopic: slow growing mold; tan, fluffy colonies; yeast in 10-15

19

Histoplasma capsulatum

card image
20

Paracoccidioides brasiliensis

NW, Central, and SE South America, Central America, and southern Mexico; soil saprobe of acid soil

21

Paracoccidioides brasiliensis

microscopic: fine septate hyaline hyphae; conidiation absent on modified SDA; yeast form multiple thin necked buds (mariners wheel)

22

Paracoccidioides brasiliensis

macroscopic: 2-3 weeks mold colony; flat, white colonies

23

Paracoccidioides brasiliensis

card image
24

Sporothrix shenckii

found worldwide; rose gardener's disease

25

Sporothrix shenckii

microscopic: mold-delicate thin hyphae, septate, frequently found as ropes, conidiophores produce multiple conidia in floweret arrangements; 2 types of conidia: small oval unicellular or large dark walled spheres; yeast is cigar shaped

26

Sporothrix shenckii

macroscopic: mold in 3-5 days at 25 colonies dark and flat; yeast at 37 white or tan

27

Sporothrix shenckii

card image
28

Sporothrix shenckii

card image
29

Talaromyces marnefei

macroscopic: fast growing, suede-like to downy, white with yellowish-green conidial heads; greyish pink to brown with age and produce a diffusable brownish-red pigment

30

Talaromyces marnefei

microscopic: BHI at 37 colonies are rough, glabrous, tan-colored and yeastlike; numerous short hyphal elements also present

31

Talaromyces marnefei

card image
32

Emmonsia spp.

clinical disease; ranges from asymptomatic to fatal; adiaspiromycosis-respiratory, emmonsiosis cutaneous

33

Emmonsia spp.

macroscopic: produce globrose, colorless colonies with yellow to white to orange to grey mycelia; PDA or Pablum Cereal Agar; yeast conversion-Phytone Yeast Extract Agar

34

Emmonsia spp.

microscopic: thick walled Adiaspores

35

Emmonsia spp.

card image
36

Emmonsia spp.

card image
37

dermatophytes

serology not necessary

38

exoantigen test-ouchterlony

rapid information of immuno-identity; extract soluble antigen from unknown isolate, concentrate, react with antiserum specific to known fungi, positive control for definitive ID, test read at 24 hours; identify blastomyces, coccidioides, and histoplasma

39

molecular

uses DNA probe, rapid kits, to identify fungi in culture; specific to fungi, but performed on culture growth, not original specimens; identifies Coccidioides, Blastomyces, and Histoplasma

40

eukaryotic

characteristic of fungi that makes drugs toxic to human cells as well as fungal cells

41

Griseofulvin

general inhibition of growth; stubborn cases of dermatophyte infections, nephrotoxic

42

Synthetic azoles

cell wall structure, broad spectrum

43

Flucytosine

cutaneous mycoses or in combination with amphotericin B for systemic mycoses

44

Echinocandins

damage cell walls; capsofungin

45

Macrolide polyene/Amphotericin B

includes Amphotericin B and Nystatin

46

Amphotericin B

mimic lipids, most versatile and effective, topical and systemic treatment

47

Nystatin

topical treatment

48

...

card image
49

...

card image
50

...

card image
51

...

card image