Chronic Myeloid Leukemia
What is the percentage of leukemia cases are CML?
What is the average age of onset?
40 - 50 years ol
Which groups does CML occasionally occur in?
childhood and adolescence
What carries the Philadelphia (Philly) chromosome?
Which chromosomes are translocated?
Chromosomes 9 and 22
What does the translocation of the 2 chromosomes cause? And what does the protein product do?
causes 2 genes that are juxtaposed and creates a new fusion gen - bcr/abl. This protein product spurs the proliferation of cells and reduces aptosis
What does the CBC show?
a high granulocyte count
What are the symptoms of CML?
abdominal pain due to splenomegaly
Which cells have a greater degree of segmentation than AML?
What does CML not respond well to?
What is the survival time of CML?
poor survival time
What is the median survival rate if CML is untreated?
What does the anti-bcr & abl therapy treatment do?
reduces number of leukemic cells with bcr/abl type to undetectable levels
What are the other treatments for CML?
allogenic BMT from suitable donor
autogenic BMT which is less effective
What is the prognosis of CML when it progresses to blast stage CML (aka AML)?
very poor prognosis