Chronic Myeloid Leukemia

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Pathophysiology
Chapter 11
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1

What is the percentage of leukemia cases are CML?

15 %

2

What is the average age of onset?

40 - 50 years ol

3

Which groups does CML occasionally occur in?

childhood and adolescence

4

What carries the Philadelphia (Philly) chromosome?

granulocytes

5

Which chromosomes are translocated?

Chromosomes 9 and 22

6

What does the translocation of the 2 chromosomes cause? And what does the protein product do?

causes 2 genes that are juxtaposed and creates a new fusion gen - bcr/abl. This protein product spurs the proliferation of cells and reduces aptosis

7

What does the CBC show?

a high granulocyte count

8

What are the symptoms of CML?

fatigue

weight loss

sweats

bleeding

abdominal pain due to splenomegaly

9

Which cells have a greater degree of segmentation than AML?

CML cells

10

What does CML not respond well to?

chemotherapy

11

What is the survival time of CML?

poor survival time

12

What is the median survival rate if CML is untreated?

2 years

13

What does the anti-bcr & abl therapy treatment do?

reduces number of leukemic cells with bcr/abl type to undetectable levels

14

What are the other treatments for CML?

allogenic BMT from suitable donor

autogenic BMT which is less effective

15

What is the prognosis of CML when it progresses to blast stage CML (aka AML)?

very poor prognosis