Hairy Cell Leukemia

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Pathophysiology
Chapter 11
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1

What type of cancer is HCL?

rare chronic type of leukemia

2

What is the percentage of adults who get HCL?

2 %

3

What is the median age?

55 years old

4

What is the ratio of predominance in males?

5:1 ratio

5

What phenotype does HCL have?

B cell

6

What is HCL?

peculiar cells with hairy like projections on their surface

7

What do the hairy cells in the peripheral blood do?

reduce the number of granulocytes, platelets and red blood cells

8

When does a patient receive treatment for HCL?

at symptomatic stage

9

What are the signs and symptoms of HCL?

enlarged spleen

recurrent infection

bleeding disorder

anemia

chronic bone pain

10

What is the current remission rate of HCL with the appropriate chemotherapy protocol?

80 %

11

What is the preferred treatment for HCL?

autologous stem cell transplant

12

How treatable is HCL in adults?

highly treatable

13

What is the percentage of patients that have splenomegaly at diagnosis?

90 %