NAT 503 Module 10 Flashcards


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Oxygen Transport and Coagulation Pathophysiology
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1

A cause of thrombocytopenia includes
hypoxemia.
reduced erythropoietin.
chemotherapy.
secondary polycythemia.

chemotherapy.

2

Activation of the extrinsic pathway of coagulation is initiated by
platelet factors.
collagen exposure.
tissue thromboplastin.
factor VII.

tissue thromboplastin.

3

Anemia related to vitamin B12 or folate deficiency is characterized by what laboratory features? (Select all that apply.)
RBC counts of 775,000 to 900,000 cells/mm3
RBC counts of 500,000 to 750,000 cells/mm3
WBC counts of 3000 to 4000 cells/mm3
WBC counts of 4000 to 5000 cells/mm3
Platelet counts of 60,000 cells/mm3

RBC counts of 500,000 to 750,000 cells/mm3
WBC counts of 4000 to 5000 cells/mm3

4

A patient presents to the physician’s office with pinpoint hemorrhages on the skin. The patient is most likely between the ages of _____ years.
6 months and 2
4 and 7
15 and 18
25 and 45

4 and 7

5

Disseminated intravascular coagulation may be treated with heparin therapy to
enhance fibrinolysis.
inhibit clotting factor consumption.
activate platelets.
enhance liver synthesis of clotting factors.

inhibit clotting factor consumption.

6

Erythropoietin is released by the:
red blood cells.
bone marrow.
spleen.
kidneys.

kidneys.

7

Most carbon dioxide is transported in the bloodstream as
carboxyhemoglobin.
bicarbonate ion.
dissolved carbon dioxide.
carbonic acid.

bicarbonate ion.

8

Patients who experience anemic episodes when exposed to certain drugs most likely have
thalassemia.
spherocytosis.
sickle cell anemia.
glucose-6-phosphate dehydrogenase deficiency.

glucose-6-phosphate dehydrogenase deficiency.

9

Thalassemia may be confused with iron-deficiency anemia, because they are both
hyperchromic.
microcytic.
genetic.
responsive to iron therapy.

microcytic.

10

The anemia resulting from a deficiency of either vitamin B12 (cobalamin) or folate is caused by a disruption in DNA synthesis of the blast cells in the bone marrow that produces very large abnormal bone marrow cells called megaloblasts.
True
False

True

11

The megakaryocyte is a precursor to
factor IX.
white blood cells.
red blood cells.
platelets.

platelets.

12

The most appropriate treatment for secondary polycythemia is
volume expansion with saline.
measured to improve oxygenation.
phlebotomy.
chemotherapy.

measured to improve oxygenation.

13

The nurse is educating a patient diagnosed with anemia of chronic renal failure about the disease. Which statements made by the nurse are correct regarding the patient’s treatment? (Select all that apply.)
“Since your glomerular filtration is 13 mL/min, you’ll be started on dialysis.”
“Your hematocrit is 29%, so you’re going to start on erythropoietin therapy.”
“Your hemoglobin is 9 g/dL, so you’ll need erythropoietin therapy.”
“We need to get your hemoglobin up to at least 15 g/dL”
“You’re going to need iron, folate, and B12 therapy to help improve your blood counts.”

“Since your glomerular filtration is 13 mL/min, you’ll be started on dialysis.”
“Your hematocrit is 29%, so you’re going to start on erythropoietin therapy.”
“Your hemoglobin is 9 g/dL, so you’ll need erythropoietin therapy.”
“You’re going to need iron, folate, and B12 therapy to help improve your blood counts.”

14

The prothrombin time (PT) and INR (international normalized ratio) measure the integrity of
platelet function.
extrinsic pathway.
intrinsic pathway.
fibrinolysis.

extrinsic pathway.

15

What laboratory finding is usually found in aplastic anemia?
Leukocytosis
Thrombocythemia
Neutrophilia
Pancytopenia

Pancytopenia

16

When plasmin degrades fibrin during the fibrinolytic process, what is (are) the by-product(s) called?
Clotting factors
Thrombopoietin
Fibrin degradation products
Tissue thromboplastin

Fibrin degradation products

17

Where in the body are clotting factors synthesized?
Bone marrow
Kidneys
Liver
Spleen

Liver

18

Which of the following is a characteristic of mature erythrocytes?
Have a spherical shape
Are produced in the spleen
Contain the protein transferrin
Have no nucleus

Have no nucleus

19

Which of the following proteins is not a normal component of plasma?
Albumin
Clotting factors
Collagen
Immunoglobulins

Collagen

20

Widespread activation of the clotting cascade secondary to massive trauma is called
hemophilia B.
disseminated intravascular coagulation (DIC).
Hageman disease.
idiopathic thrombocytopenia purpura.

disseminated intravascular coagulation (DIC).