Pharmacology Week 1 & 2

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created 2 weeks ago by clarissajeffries
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Drugs: fluphenazine, haloperidol, quetiapine, aripiprazole, benztropine mesylate (Cogentin), lorazepam, diazepam, fluoxetine, venlafaxine, bupropion, trazodone, lithium, carbamazepine
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1

fluphenazine: antipsychotic

Indications:

Side Effects: Hyper/hypotension, tachycardia, ileus, EPS, seizures, psychosis, hyper/hypoglycemia, hyponatremia, cerebral edema, pseudoparkinsonismLife threatening: Agranulocytosis, aplastic anemia, hemolytic anemia, leukopenia, eosinophilia, neutropenia, thrombocytopenia, angioedema, bronchospasm, NMS

Nursing: watch for suicidal ideation, and alcoholism

2

haloperidol: Haldol Therapeutic: antipsychotics

Indications:

Side Effects: NEUROLEPTIC MALIGNANT SYNDROME, hypersensitivity reactions. Siezures, blurred vision, dry eyes, constipation, dry mouth

Nursing: Monitor for development of neuroleptic malignant syndrome (fever, respiratory distress, tachycardia, seizures, diaphoresis, hypertension or hypotension, pallor, tiredness, severe muscle stiffness, loss of bladder control). Watch liver function

3

quetiapine: SEROquel Therapeutic: antipsychotics, mood stabilizers

Indications: Schizophrenia. Depressive episodes with bipolar disorder. Acute manic episodes associated with bipolar I disorder.

Side Effects: NEUROLEPTIC MALIGNANT SYNDROME, SEIZURES, dizziness STEVENS-JOHNSON SYNDROME AGRANULOCYTOSIS,

Nursing Implications: assess for suicidal ideation/ tendencies. monitor for side effects.

4

aripiprazole Abilify:

Therapeutic: antipsychotics, mood stabilizers

Pharmacologic: serotonin-dopamine activity modulators (SDAM)

Indications: Schizophrenia Acute treatment of manic and mixed episodes associated with bipolar I disorder

Side Effects: suicidal thoughts, AGRANULOCYTOSIS, HYPERSENSITIVITY REACTIONS, NEUROLEPTIC MALIGNANT SYNDROME, confusion, impulse control disorder.

Nursing Implications: monitor for side effects, watch for suicidal ideation increased in minors

5

benztropine mesylate (Cogentin): anticholinergic

Therapeutic: antiparkinson agents

Pharmacologic: anticholinergics

Indications: treatment for Parkinsons disease

side effects: dry eyes, dry mouth, constipation, urinary retention, confusion, drowsy, dizzy, hallucinations

nursing implications: PO - admin with food. teach about orthostatic hypotension

6

lorazepam: benzodiazepines

indications: anxiety disorder, status epilipticus

side effects: dizzy, drowsy, apnea, cardiac arrest, contraindicated with other CNS depressants

nursing implications: assess for CNS depression esp. in GERI and PEDS

7

diazepam: Pharmacologic: benzodiazepines

indications: antianxiety agents, anticonvulsants, sedative/hypnotics, skeletal muscle relaxants (centrally acting)

side effects: Conscious sedation (provides light anesthesia and anterograde amnesia

8

fluoxetine

antidepressants

Pharmacologic: selective serotonin reuptake inhibitors (SSRIs)

indications: Major depressive disorder. OCD. Bulimia. Panic disorder. Acute treatment of depressive episodes associated with bipolar I disorder

side effects: NEUROLEPTIC MALIGNANT SYNDROME, SEIZURES, SUICIDAL THOUGHTS TORSADES DE POINTES, chest pain, palpitations SEROTONIN SYNDROME

nursing implications: Discontinue use of MAO inhibitors for 14 days before fluoxetine therapy Assess for suicidal tendencies, especially during early therapy.

9

venlafaxine

Therapeutic: antidepressants, antianxiety agents

Pharmacologic: selective serotonin/norepinephrine reuptake inhibitors

Indications: Major depressive, generalized anxiety, social anxiety, panic disorder, PMDD

side effects: NEUROLEPTIC MALIGNANT SYNDROME, SEIZURES, SUICIDAL THOUGHTS, emotional liabilty, worsening depression, chest pain and palp. tachy

nursing implications: Concurrent use with MAO inhibitors may result in serious, potentially fatal reactions assess for suicidal tendancies, assess for seretonin syndrome

10

bupropion antidepressants, smoking deterrents

indications: depression, seasonal affective disorder, smoking cessation, treatment of ADHD. increase sexual desire in women.

side effects: homicidal/suicidal thoughts/behaviors, seizures, insomnia, mania

nursing implications: No MAO inhibitors, assess mental status in all patients. watch closely in pts. with renal or hepatic impairment

11

trazodone antidepressants

indications: major depressions, insomnia, diabetic neuropathy, chronic pain syndromes

side effects: suicidal thoughts, dizzyness, fatigue, insomnia, hypotension, chest pain, arrhythmias

nursing implications: No MAO inhibitors, assess for suicidal tendencies, assess for seretonin syndrome, assess

12

lithium: mood stabilizers

Indications: Treatment of acute manic and mixed episodes associated with bipolar I disorder

side effects: tremors, dry mouth, GI distress, drowsy, edema in hands and ankles (it is a salt), dehydration, seizures, serotonin syndrome

nursing implications: no caffeine or loop diuretics assess for suicidal ideation, watch for manic behavior. watch for lithium toxicity due to small therapeutic window 1-1.5.

13

carbamazepine Therapeutic: anticonvulsants, mood stabilizers

indications: Treatment of tonic-clonic, mixed, and complex-partial seizures Acute manic or mixed episodes associated with bipolar I disorder. Unlabeled Use: Other forms of neurogenic pain.

side effects: suicidal thoughts, HEPATOTOXICITY, PANCREATITIS, ↑ liver enzymes,, DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS, AGRANULOCYTOSIS, APLASTIC ANEMIA, THROMBOCYTOPENIA, urinary retention

nursing implications: Monitor for signs and symptoms of DRESS syndrome and suicidal thoughts