Anti-Epileptics: Broad Spectrum Flashcards

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1

Anti-Epileptics: Broad Spectrum

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Divalproex Sodium

Depakote

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Mechanism of Action: Divalproex Sodium

Divalproex sodium is a stable compound comprised of sodium valproate and valproic acid in a 1:1 molar relationship. It is an antiepileptic that dissociates into valproate ion in the gastrointestinal tract. It has and unknown mechanism of action although it is suggested that its antiepileptic action may be attributed to an increased gamma-aminobutyric acid (GABA) levels in the brain

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FDA Indications: Divalproex Sodium

  • Seizures
  • Manic Bipolar Disorder
  • Migraine prevention
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What is the Pregnancy Category of Divalproex Sodium?

Pregnancy Category D/X

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Adverse Effects of Divalproex Sodium

  • Alopecia
  • Weight Gain
  • N/V
  • HA
  • Anorexia
  • Abdominal Pain
  • Dizziness
  • Somnolence
  • Tremor
  • Edema
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Patient Counseling Tips

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Patients taking Divalproex Sodium should be advised patient to report symptoms of ____________ and ____________

  • Hepatoxicity
  • Pancreatitis
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Patients taking Divalproex Sodium should be advised to take with food to minimize __________.

GI Irritation

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Patients taking Divalproex Sodium should advised to report medication residue in the __________.

Stool

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TRUE or FALSE

Patients taking Divalproex Sodium should be instructed to report worsening depression, suicidal ideation, or unusual changes in behavior.

TRUE