Anti-Epileptics: Broad Spectrum
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Divalproex Sodium
Depakote
Mechanism of Action: Divalproex Sodium
Divalproex sodium is a stable compound comprised of sodium valproate and valproic acid in a 1:1 molar relationship. It is an antiepileptic that dissociates into valproate ion in the gastrointestinal tract. It has and unknown mechanism of action although it is suggested that its antiepileptic action may be attributed to an increased gamma-aminobutyric acid (GABA) levels in the brain
FDA Indications: Divalproex Sodium
- Seizures
- Manic Bipolar Disorder
- Migraine prevention
What is the Pregnancy Category of Divalproex Sodium?
Pregnancy Category D/X
Adverse Effects of Divalproex Sodium
- Alopecia
- Weight Gain
- N/V
- HA
- Anorexia
- Abdominal Pain
- Dizziness
- Somnolence
- Tremor
- Edema
Patient Counseling Tips
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Patients taking Divalproex Sodium should be advised patient to report symptoms of ____________ and ____________
- Hepatoxicity
- Pancreatitis
Patients taking Divalproex Sodium should be advised to take with food to minimize __________.
GI Irritation
Patients taking Divalproex Sodium should advised to report medication residue in the __________.
Stool
TRUE or FALSE
Patients taking Divalproex Sodium should be instructed to report worsening depression, suicidal ideation, or unusual changes in behavior.
TRUE