Anticoagulant: Warfarin Flashcards
Mechanism of Action: Warfarin
Warfarin completely inhibits the C1 subunit of multi-unit Vitamin K epoxide reductase (VKORC1) enzyme complex causing depletion of clotting factors 2, 7, 9, 10 and protein C and S.
FDA Indications: Warfarin
- Atrial Fibrillation
- Prosthetic cardiac valve component embolism
- Pulmonary embolism
- Venous thromboembolism
Adverse Effects of Warfarin
- Unusual and unexpected bleeding
What Pregnancy Category is Warfarin?
Pregnancy Category X
Patient Counseling Tips
Patients should be advised to take Warfarin at the _________ everyday without regard to food.
Patients taking Warfarin should be advised that they will need to have their blood tested frequently to check their __________.
Patients taking Warfarin should be advised to not make changes in diet such as eating large amounts of green leafy foods as they contain a large amount of ____________.
Patients taking Warfarin are advised to not drink ______.
Patients taking Warfarin should be advised that they can experience _____ _____ syndrome that can cause toes to become painful and purple in color.
Purple Toe Syndrome