Anticoagulant: Warfarin Flashcards
Anticoagulant
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Warfarin
- Coumadin
- Jantoven
Mechanism of Action: Warfarin
Warfarin completely inhibits the C1 subunit of multi-unit Vitamin K epoxide reductase (VKORC1) enzyme complex causing depletion of clotting factors 2, 7, 9, 10 and protein C and S.
FDA Indications: Warfarin
- Atrial Fibrillation
- Prosthetic cardiac valve component embolism
- Pulmonary embolism
- Thrombosis
- Venous thromboembolism
Adverse Effects of Warfarin
- Unusual and unexpected bleeding
- Alopecia
- Fever
- N/D
- Dermatitis
What Pregnancy Category is Warfarin?
Pregnancy Category X
Patient Counseling Tips
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Patients should be advised to take Warfarin at the _________ everyday without regard to food.
Sametime
Patients taking Warfarin should be advised that they will need to have their blood tested frequently to check their __________.
INR
Patients taking Warfarin should be advised to not make changes in diet such as eating large amounts of green leafy foods as they contain a large amount of ____________.
Vitamin K
Patients taking Warfarin are advised to not drink ______.
Alcohol
Patients taking Warfarin should be advised that they can experience _____ _____ syndrome that can cause toes to become painful and purple in color.
Purple Toe Syndrome