Atypical Antidepressant/Serotonin Modulator
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Trazodone Hydrochloride
- Desyrel
- Oleptro
Mechanism of Action of Trazodone
Trazodone inhibits serotonin reuptake by brain synaptosomes therefore increasing the behavioral effects of the serotonin precursor 5-hydroxytryptophan (5-HT)
FDA Indications: Trazodone
Major Depressive Disorder
RX Prep Book:
Trazodone is RARELY used for depression due to sedation. It is mainly used off-label for sleep.
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Adverse Effects of Trazodone
- Nausea
- Xerostomia (dry mouth)
- Somnolence (sleepiness)
- Blurred Vision
- HA
- Feeling Nervous
- Fatigue
Patient Counseling Tips
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Patients should be advised that Trazodone causes drowsiness and should be taken at ____________.
Bedtime
Male patients taking Trazodone should be counseled to contact PCP if they experience an _________ lasting longer than 4 hours.
erection
Patients should be advised to take Trazodone at bedtime with food to enhance ________________.
absorption
True or False
Patients should avoid alcohol while taking this medication.
TRUE
Patients taking Trazodone should be advised to use caution when operating machinery as it can cause severe __________.
Sedation