Atypical Antidepressant/Serotonin Modulator Flashcards

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1

Atypical Antidepressant/Serotonin Modulator

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2

Trazodone Hydrochloride

  1. Desyrel
  2. Oleptro

3

Mechanism of Action of Trazodone

Trazodone inhibits serotonin reuptake by brain synaptosomes therefore increasing the behavioral effects of the serotonin precursor 5-hydroxytryptophan (5-HT)

4

FDA Indications: Trazodone

Major Depressive Disorder

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RX Prep Book:

Trazodone is RARELY used for depression due to sedation. It is mainly used off-label for sleep.

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Adverse Effects of Trazodone

  • Nausea
  • Xerostomia (dry mouth)
  • Somnolence (sleepiness)
  • Blurred Vision
  • HA
  • Feeling Nervous
  • Fatigue

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Patient Counseling Tips

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Patients should be advised that Trazodone causes drowsiness and should be taken at ____________.

Bedtime

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Male patients taking Trazodone should be counseled to contact PCP if they experience an _________ lasting longer than 4 hours.

erection

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Patients should be advised to take Trazodone at bedtime with food to enhance ________________.

absorption

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True or False

Patients should avoid alcohol while taking this medication.

TRUE

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Patients taking Trazodone should be advised to use caution when operating machinery as it can cause severe __________.

Sedation