Antidiabetic: Biguanide Flashcards
Mechanism of Action: Metformin
Metformin decreases hyperglycemia by decreasing hepatic glucose production, decreasing intestinal absorption of glucose, and increasing insulin sensitivity.
FDA Indications: Metformin
- Type 2 Diabetes Mellitus
Most Common Adverse Events: Metformin
- B12 Deficiency
- Malabsorption Syndrome
Patient Counseling Tips
Patients should be advised to take Metformin with ______ to prevent GI upset.
NOTE: Patients may experience N/V/D, abdominal discomfort, and flatulence.
What rare life threatening condition can be developed while taking Metformin?
Patients should be counseled to monitor for the following symptoms as it may indicate Lactic Acidosis:
- Feeling weak or tired
- Slow or irregular heartbeat
- Unusual muscle pain
- Trouble breathing
- Unusual stomach pain
- Feeling cold
Patients should be advised to temporarily stop taking Metformin if they are having any type of procedure using _______ ________.
Patient ____________-release formulations of Metformin can leave shell casing in stool.
Patients should be advised to not break, chew, or crush _________ __________ formulations of Metformin.
Patients taking Metformin should be advised that long-term use can cause _______ deficiency.