Antidepressants: SSRIs Flashcards


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1

Selective Serotonin Reuptake Inhibitors (SSRIs)

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2

Mechanism of Action: SSRIs

SSRIs increase serotonin (5-HT) by inhibiting its reuptake (reabsorption) in the neuronal synapse.

NOTE: SSRIs also weakly affect (Norepinephrine) NE and (Dopamine) DA.

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Sertraline

Zoloft

4

Escitalopram

Lexapro

5

Citalopram

Celexa

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Fluoxetine

  • Prozac
  • Sarafem
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Paroxetine

  1. Paxil
  2. Pexeva
  3. Brisdelle
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Fluvoxamine IR/ER

N/A

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What are the 6 SSRIs?

  1. Sertraline (Zoloft)
  2. Citalopram (Celexa)
  3. Escitalopram (Lexapro)
  4. Fluoxetine (Prozac)
  5. Paroxetine (Paxil)
  6. Fluvoxamine
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Most Common Adverse Effects of SSRIs

  • N/V/D
  • HA
  • Reduced Libido/Abnormal Ejaculation
  • Tremor
  • Somnolence
  • Insomnia
  • Dizziness
  • Fatigue
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FDA Indications: Sertraline (Zoloft)

  1. Major Depressive Disorder
  2. Panic Disorder
  3. OCD
  4. PTSD
  5. Social Phobia
  6. Premenstrual Dysphoric Disorder
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FDA Indications: Escitalopram (Lexapro)

1. Generalized Anxiety Disorder

2. Major Depressive Disorder

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FDA Indications: Fluoxetine (Prozac)

  1. Bulimia Nervosa
  2. Panic Disorder
  3. OCD
  4. Social Phobia
  5. Premenstrual Dysphoric Disorder
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FDA Indications: Citalopram (Celexa)

  • Depression
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*RX PREP BOOK STATED:*

ALL SSRIs are approved for depression and a variety of anxiety disorders!

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16

Which SSRI is Pregnancy Category D?

Paroxetine (Paxil)

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Patient Counseling Tips

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18

Patients taking ________ should be advised that it is the most activating SSRI and can keep you awake.

Fluoxetine (Prozac)

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When should Fluoxetine (Prozac) be taken?

Fluoxetine (Prozac) should be taken in the morning (QAM)

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Patients taking SSRIs should be advised to avoid starting OTC drugs without notifying their doctor due to possible drug interactions resulting in ___________ syndrome.

Serotonin

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Serotonin Syndrome is characterized by the following symptoms:

  1. Tachycardia (racing heartbeat)
  2. Hallucinations
  3. Feeling very agitated
  4. Severe N/D
  5. Severe HA
  6. Severe dizziness
22

Patients should be advised that SSRIs can cause __________ __________.

Sexual Difficulties

NOTE: Patients should contact their doctor to consider being switched to another agent that does not have these effects.

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Patients should be advised that SSRIs cannot be abruptly discontinued. Patient MUST be _________ off.

Tapered