Antidepressants: SSRIs Flashcards

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1

Selective Serotonin Reuptake Inhibitors (SSRIs)

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2

Mechanism of Action: SSRIs

SSRIs increase serotonin (5-HT) by inhibiting its reuptake (reabsorption) in the neuronal synapse.

NOTE: SSRIs also weakly affect (Norepinephrine) NE and (Dopamine) DA.

3

Sertraline

Zoloft

4

Escitalopram

Lexapro

5

Citalopram

Celexa

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Fluoxetine

  • Prozac
  • Sarafem

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Paroxetine

  1. Paxil
  2. Pexeva
  3. Brisdelle

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Fluvoxamine IR/ER

N/A

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What are the 6 SSRIs?

  1. Sertraline (Zoloft)
  2. Citalopram (Celexa)
  3. Escitalopram (Lexapro)
  4. Fluoxetine (Prozac)
  5. Paroxetine (Paxil)
  6. Fluvoxamine

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Most Common Adverse Effects of SSRIs

  • N/V/D
  • HA
  • Reduced Libido/Abnormal Ejaculation
  • Tremor
  • Somnolence
  • Insomnia
  • Dizziness
  • Fatigue

11

FDA Indications: Sertraline (Zoloft)

  1. Major Depressive Disorder
  2. Panic Disorder
  3. OCD
  4. PTSD
  5. Social Phobia
  6. Premenstrual Dysphoric Disorder

12

FDA Indications: Escitalopram (Lexapro)

1. Generalized Anxiety Disorder

2. Major Depressive Disorder

13

FDA Indications: Fluoxetine (Prozac)

  1. Bulimia Nervosa
  2. Panic Disorder
  3. OCD
  4. Social Phobia
  5. Premenstrual Dysphoric Disorder

14

FDA Indications: Citalopram (Celexa)

  • Depression

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*RX PREP BOOK STATED:*

ALL SSRIs are approved for depression and a variety of anxiety disorders!

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16

Which SSRI is Pregnancy Category D?

Paroxetine (Paxil)

17

Patient Counseling Tips

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18

Patients taking ________ should be advised that it is the most activating SSRI and can keep you awake.

Fluoxetine (Prozac)

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When should Fluoxetine (Prozac) be taken?

Fluoxetine (Prozac) should be taken in the morning (QAM)

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Patients taking SSRIs should be advised to avoid starting OTC drugs without notifying their doctor due to possible drug interactions resulting in ___________ syndrome.

Serotonin

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Serotonin Syndrome is characterized by the following symptoms:

  1. Tachycardia (racing heartbeat)
  2. Hallucinations
  3. Feeling very agitated
  4. Severe N/D
  5. Severe HA
  6. Severe dizziness

22

Patients should be advised that SSRIs can cause __________ __________.

Sexual Difficulties

NOTE: Patients should contact their doctor to consider being switched to another agent that does not have these effects.

23

Patients should be advised that SSRIs cannot be abruptly discontinued. Patient MUST be _________ off.

Tapered