Antidepressants: SSRIs Flashcards
Selective Serotonin Reuptake Inhibitors (SSRIs)
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Mechanism of Action: SSRIs
SSRIs increase serotonin (5-HT) by inhibiting its reuptake (reabsorption) in the neuronal synapse.
NOTE: SSRIs also weakly affect (Norepinephrine) NE and (Dopamine) DA.
Sertraline
Zoloft
Escitalopram
Lexapro
Citalopram
Celexa
Fluoxetine
- Prozac
- Sarafem
Paroxetine
- Paxil
- Pexeva
- Brisdelle
Fluvoxamine IR/ER
N/A
What are the 6 SSRIs?
- Sertraline (Zoloft)
- Citalopram (Celexa)
- Escitalopram (Lexapro)
- Fluoxetine (Prozac)
- Paroxetine (Paxil)
- Fluvoxamine
Most Common Adverse Effects of SSRIs
- N/V/D
- HA
- Reduced Libido/Abnormal Ejaculation
- Tremor
- Somnolence
- Insomnia
- Dizziness
- Fatigue
FDA Indications: Sertraline (Zoloft)
- Major Depressive Disorder
- Panic Disorder
- OCD
- PTSD
- Social Phobia
- Premenstrual Dysphoric Disorder
FDA Indications: Escitalopram (Lexapro)
1. Generalized Anxiety Disorder
2. Major Depressive Disorder
FDA Indications: Fluoxetine (Prozac)
- Bulimia Nervosa
- Panic Disorder
- OCD
- Social Phobia
- Premenstrual Dysphoric Disorder
FDA Indications: Citalopram (Celexa)
- Depression
*RX PREP BOOK STATED:*
ALL SSRIs are approved for depression and a variety of anxiety disorders!
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Which SSRI is Pregnancy Category D?
Paroxetine (Paxil)
Patient Counseling Tips
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Patients taking ________ should be advised that it is the most activating SSRI and can keep you awake.
Fluoxetine (Prozac)
When should Fluoxetine (Prozac) be taken?
Fluoxetine (Prozac) should be taken in the morning (QAM)
Patients taking SSRIs should be advised to avoid starting OTC drugs without notifying their doctor due to possible drug interactions resulting in ___________ syndrome.
Serotonin
Serotonin Syndrome is characterized by the following symptoms:
- Tachycardia (racing heartbeat)
- Hallucinations
- Feeling very agitated
- Severe N/D
- Severe HA
- Severe dizziness
Patients should be advised that SSRIs can cause __________ __________.
Sexual Difficulties
NOTE: Patients should contact their doctor to consider being switched to another agent that does not have these effects.
Patients should be advised that SSRIs cannot be abruptly discontinued. Patient MUST be _________ off.
Tapered