Proton Pump Inhibitors (PPIs) Flashcards


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created 2 years ago by AWilson274
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1

Omeprazole

Prilosec

2

Pantoprazole

Protonix

3

Esomeprazole

Nexium

4

Lansoprazole

Prevacid

5

Dexlansoprazole

Dexilant

6

Mechanism of Action of PPIs

PPI's irreversibly bind to the gastric H+/K+ ATPase pump parietal cells. This shuts down the proton pump and blocks gastric acid secretion.

7

FDA Indications: PPIs

  • Erosive esophagitis
  • GERD
  • Active Gastric Ulcer
  • Helicobacter pylori gastrointestinal tract infection
  • Ulcer of duodenum
8

Major Common Adverse Effects: PPIs

  • HA
  • Nausea
  • Diarrhea

NOTE: ALL Side Effects are rare, mild, and infrequent!

9

Patient Counseling Tips

...

10

Which PPI should a patient be counseled to take 30 minutes before eating?

Omeprazole (Prilosec)

11

Patients should be advised that PPIs do NOT work immediately. They must take it ________ to get relief.

everyday

12

Patients should be advised that the risk of getting severe _______, caused by an infection in your intestines is increased with PPIs.

Diarrhea

NOTE: Patient should monitor for watery stool, stomach pain, and fever that doesn't go away.

13

Patients should be advise that using PPIs for longer than 1 year increased risk of ____ _____.

Bone Fractures

14

Due to increased of bone fractures when taking PPIs for longer than 1 year, patients should be advised to make sure their __________ and ______ intake is optimal.

  • Vitamin D and Calcium
15

When taking PPIs, which calcium supplementation is recommended for bone health if needed?

Calcium Citrate

16

Patients taking PPIs should NOT stop this medication abruptly because they may experience ____ ______.

Acid rebound

17

Patients should be advised that PPI tablets or capsules should NOT be _____ or _______.

Crushed or Chewed

NOTE: However, contents in capsules can be taken with applesauce and a cool glass of water if patient is having difficulty swallowing.

18

Patients should be advise that PPIs can cause low levels of ______________.

Magnesium

19

Patients should be advised to monitor for the following symptoms when taking PPIs as these may indicate low magnesium levels:

  • Dizziness
  • Jitteriness
  • Abnormal heartbeat
  • Seizures
  • Jerking movement or Shaking
  • Weak, Cramping, or Aching Muscles
20

Patients can take _______ at the same time as PPIs.

Antacids