Mechanism of Action of PPIs
PPI's irreversibly bind to the gastric H+/K+ ATPase pump parietal cells. This shuts down the proton pump and blocks gastric acid secretion.
FDA Indications: PPIs
- Erosive esophagitis
- Active Gastric Ulcer
- Helicobacter pylori gastrointestinal tract infection
- Ulcer of duodenum
Major Common Adverse Effects: PPIs
NOTE: ALL Side Effects are rare, mild, and infrequent!
Patient Counseling Tips
Which PPI should a patient be counseled to take 30 minutes before eating?
Patients should be advised that PPIs do NOT work immediately. They must take it ________ to get relief.
Patients should be advised that the risk of getting severe _______, caused by an infection in your intestines is increased with PPIs.
NOTE: Patient should monitor for watery stool, stomach pain, and fever that doesn't go away.
Patients should be advise that using PPIs for longer than 1 year increased risk of ____ _____.
Due to increased of bone fractures when taking PPIs for longer than 1 year, patients should be advised to make sure their __________ and ______ intake is optimal.
- Vitamin D and Calcium
When taking PPIs, which calcium supplementation is recommended for bone health if needed?
Patients taking PPIs should NOT stop this medication abruptly because they may experience ____ ______.
Patients should be advised that PPI tablets or capsules should NOT be _____ or _______.
Crushed or Chewed
NOTE: However, contents in capsules can be taken with applesauce and a cool glass of water if patient is having difficulty swallowing.
Patients should be advise that PPIs can cause low levels of ______________.
Patients should be advised to monitor for the following symptoms when taking PPIs as these may indicate low magnesium levels:
- Abnormal heartbeat
- Jerking movement or Shaking
- Weak, Cramping, or Aching Muscles
Patients can take _______ at the same time as PPIs.