Calcium Channel Blockers (CCB's) Flashcards


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created 2 years ago by AWilson274
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1

CCBs: Dihydropyridines (DHP)

DHP-CCBs end in "-pine"

2

Amlodipine

Norvasc

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Nifedipine IR

  1. Procardia

4

Nifedipine ER

  1. Adalat CC
  2. Procardia XL

5

Mechanism of Action of DHP-CCB

DHP-CCB inhibits Ca+ ions from entering vascular smooth muscle and myocardial cells (cardiac muscle) causing peripheral arterial vasodilation and coronary artery vasodilation.

6

FDA Indications of DHP-CCBs

  1. Hypertension
  2. Chronic Stable Angina
  3. Prinzmetal's Angina (Vasospastic Angina)
  4. Coronary arteriosclerosis

7

Most Common Adverse Effects of DHP-CCBs

  • Peripheral Edema
  • Flushing
  • HA

8

Patient Counseling Tips

...

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Which DHP-CCB can leave an empty shell in your stool?

Nifedipine ER (Adalat CC and Procardia XL)

NOTE: Inform patient that empty shell is nothing to worry about.

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Which DHP-CCB should be taken on a empty stomach?

Nifedipine ER (Adalat CC)

11

When taking DHP-CCBs patients should avoid drinking _______ juice.

Grapefruit

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Patients should be informed that DHP-CCBs can cause the following side effects:

  1. Swelling in the ankles (edema)
  2. Feeling tired
  3. Dizziness
  4. HA
  5. Hot or Warm feelings in the face
  6. Palpitations

13

TRUE or FALSE

While taking DHP-CCBs, patients should be counseled to not take OTC Cough/Cold medicines without consulting a doctor.

TRUE

14

CCBs: Non-Dihydropyridines (DHP)

...

15

Diltiazem

  1. Cardizem
  2. Cartia
  3. Tiazac

16

Verapamil

  1. Calan
  2. Verelan

17

MOA of Non-DHP's

DHP-CCB inhibits Ca+ ions from entering vascular smooth muscle and myocardial cells (cardiac muscle) causing peripheral arterial vasodilation and coronary artery vasodilation.

DIFFERENCE: They are more selective than the DHP CCB's

18

FDA Indications of Non-DHPs

1. Atrial arrhythmia

2. Hypertension

3. Paroxysmal supraventricular tachycardia

4. Stable angina

19

Most Common Adverse Effects of Non-DHP CCB's

  • Edema
  • HA
  • Gingival Hyperplasia
  • Constipation (more with Verapamil)

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Non-DHP CCB's can worsen symptoms of _____ _______.

Heart failure

21

Non-DHP CCB's have negative ______ and _______ effects.

  1. Inotropic
  2. Chronotropic

22

Non-DHP CCBs should not be used in patients with pulmonary _________, acute MI, or an ___________

  1. Pulmonary congestion
  2. AV Block