Mechanism of Action: Statins
Statins are HMG-CoA Reductase Inhibitors
NOTE: Statins are responsible for converting HMG-CoA to mevalonate, an early rate-limiting step in the synthesis of cholesterol.
FDA Indication for Statins
- Prophylaxis - CVD
- High cholesterol
- High triglycerides
- Familial hypercholesterolemia
What is the Pregnancy Category of Statins?
Pregnancy Category X
Most Common Adverse Effects of Statins
- Myalgia (Rhabdomyolysis)
- Arthralgia (joint pain)
Which 3 Statins should be taken in the evening (at bedtime)?
- Simvastatin (Zocor)
- Fluvastatin (Lescol)
- Lovastatin (Altoprev)
Patient Counseling Tips
Patients taking statins should contact their doctor if they experience muscle weakness, tenderness, aching, cramps, stiffness or pain that happens without a good reason, especially if they have a fever or feel more tired than usual. These may be symptoms of ______ __________.
Patients taking Statins should contact their doctor if they are passing brown or dark-colored urine, have pale stools, feel more tired than usual or if your skin and/or whites of eyes are turning yellow. This may be a sign of ________ ________.
Statins can cause ________ and _________ damage.
Muscle and liver damage
When taking Statins, patients should NOT consume _______ juice.
NOTE: Grapefruit juice increases plasma levels of Statins in the body increasing likelihood of toxicity.
TRUE or FALSE
Statins are safe in pregnant patients.
Statins are Pregnancy Category X and can harm the fetus.
Patients taking Statins should be advised to wear sunscreen and appropriate clothing because Statins can cause ___________.
Which Statin should be taken in the bedtime? SATA