High Cholesterol Medications: Statins Flashcards


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created 2 years ago by AWilson274
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1

Atorvastatin

Lipitor

2

Pravastatin

Pravachol

3

Simvastatin

Zocor

4

Lovastatin

Altoprev

5

Mechanism of Action: Statins

Statins are HMG-CoA Reductase Inhibitors

NOTE: Statins are responsible for converting HMG-CoA to mevalonate, an early rate-limiting step in the synthesis of cholesterol.

6

FDA Indication for Statins

  • Prophylaxis - CVD
  • High cholesterol
  • High triglycerides
  • Familial hypercholesterolemia
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What is the Pregnancy Category of Statins?

Pregnancy Category X

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Most Common Adverse Effects of Statins

  • Myalgia (Rhabdomyolysis)
  • Diarrhea
  • Arthralgia (joint pain)
9

Which 3 Statins should be taken in the evening (at bedtime)?

  1. Simvastatin (Zocor)
  2. Fluvastatin (Lescol)
  3. Lovastatin (Altoprev)
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Patient Counseling Tips

...

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Patients taking statins should contact their doctor if they experience muscle weakness, tenderness, aching, cramps, stiffness or pain that happens without a good reason, especially if they have a fever or feel more tired than usual. These may be symptoms of ______ __________.

Muscle damage

12

Patients taking Statins should contact their doctor if they are passing brown or dark-colored urine, have pale stools, feel more tired than usual or if your skin and/or whites of eyes are turning yellow. This may be a sign of ________ ________.

Liver damage

13

Statins can cause ________ and _________ damage.

Muscle and liver damage

14

When taking Statins, patients should NOT consume _______ juice.

Grapefruit Juice

NOTE: Grapefruit juice increases plasma levels of Statins in the body increasing likelihood of toxicity.

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TRUE or FALSE

Statins are safe in pregnant patients.

FALSE

Statins are Pregnancy Category X and can harm the fetus.

16

Patients taking Statins should be advised to wear sunscreen and appropriate clothing because Statins can cause ___________.

Photosensitivity

17

Which Statin should be taken in the bedtime? SATA

a. Atorvastatin

b. Simvastatin

c. Pravastatin

d. Lovastatin

b. Simvastatin

d. Lovastatin