PDA II Exam II Wu

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created 11 days ago by YaniseHurt
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1

Where is 5-HT implicated

CNS

2

What are the main roles

Vasodilation

Vasoconstriction

Body Temp

Sleep

Hormone

Depression

3

What are the classes of antidepressants

TCA

SSRI

SNRI

MAOI

4

Is Fluoxetine R or S

Racemic mixture

5

What is an essential Fluoxetine derivative

Paroxetine

6

What is Paroxetine

A constrained analogue of fluoxetine

7

A smaller SAR Ki means

More potent inhibition

8

What are the structural changes that occur with Chlorpromazine

Demethylation

Sulfoxidized

Hydroxylated

Glucuronidation

9

What are Chlorpromazine derivatives

Phenothiazine

Thioxanthenes

10

What are examples of long acting neuroleptics

Fluphenazine

11

How can the DOA be increased

Preparing a long chain FA ester prodrugs

12

What are the benefits of this

Increase pt compliance

Decrease drug malabsorption

13

Where do these drug go after injections

The muscles

14

What will the muscles do to this lipophilic molecule

Release it slowly in to the blood stream (circulation)

15

What will happen once released

It will be hydrolyzed

16

What is the benefit of having -OH on molecules

Formation of an ester prodrug resulting in a FA chain and increased DOA

17

What is 1 way to increase DA levels in CNS

Administer L-DOPA (levodopa)

18

Why cant DA be administered directly

It cannot cross the BBB

19

Why

Because it is protonated/ ionized

20

What is its pKb

3.4

21

What is the pKb of L-DOPA

5.3

22

Can it pass the BBB

Yes

23

Why

Because it is less protonated than DA

24

What DA Agonist is used for PD

Apomorphine- D1/ D2 agonist

25

Can is cross the BBB

Yes, it is lipophilic

26

What is the function of Amantadine

Releases DA from storage sites and delay reuptake

27

What increases its lipophilicity

The cage structure

28

What other drug does it work well with

Levodopa

29

What antagonist is used for PD

ACH