POP 4 Drug Quiz 1 - MOA

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1

Butterbur

smooth muscle relaxant activity on vascular walls with a particular affinity for cerebral blood vessels; decrease blood concentrations of histamine and leukotrienes

2

Calcium carbonate

Calcium salts neutralize gastric acidity.

3

Goldenseal

has antimicrobial activity and prevents adherence of bacterial to host cells

4

Niacin

Not well defined

5

Saw Palmetto

multiple sites of action related to its use for BPH symptoms

6

Aluminum acetate

provides temporary relief of minor skin irritations (eg, insect bites, athlete’s foot, poison ivy, and other contact dermatitis); helps relieve itching, has a cooling and drying effect, and is particularly useful on wet or weeping lesions

7

Artificial saliva

Replace or supplement naturally produced saliva with product that has similar moisturizing characteristics to lubricate and protect the oral mucosa.

8

Benzoyl peroxide

antibacterial, comedolytic, and sebostatic agent; has bactericidal activity against Propionibacterium acnes and Staphylococcus epidermidis; has drying activity, reduces excess sebum, and produces mild desquamation, resolving acne lesions

9

Bismuth subsalicylate

antibacterial activity, protective effects on the gastric mucosa, binding of the ulcer base and mucus, and binding of bile acids

10

Cetirizine

competitively inhibits the interaction of histamine with H1 receptors, thereby preventing the allergic response

11

Chlorpheniramine

specifically blocks the H1 receptor, which inhibits the action of histamine

12

Clotrimazole

inhibits biosynthesis of ergosterol or other sterols, damaging the fungal cell wall membrane, and altering its permeability

13

Colloidal oatmeal

has protective and water-holding functions, providing moisturizing activity; contains various phenols that confer antioxidant and anti-inflammatory activity, providing temporary relief from pruritus

14

Cromolyn sodium

reduces symptoms of runny, itchy nose, congestion, and sneezing associated with rhinitis by producing mast-cell protective effects against antigen-antibody reactions (IgE-type) and blocking liberation of mediators of anaphylaxis, such as histamine

15

Docosanol

inhibits entry of the virus into the cell and fusion between the plasma membrane and the viral envelope (replication is blocked)

16

Doxylamine

competes with histamine for H1-receptor sites

17

Esomeprazole

covalently binds to H+/K+-ATPase (proton pump), which is the final pathway for acid secretion; produces a profound and prolonged antisecretory effect, and inhibits basal, nocturnal, pentagastrin-stimulated, and food-stimulated gastric acid secretio

18

Famotidine

competitive inhibitor of histamine H2 receptors; inhibition of gastric secretion

19

Fexofenadine

antihistamine with selective peripheral H1-receptor antagonist activity

20

Phenylephrine systemic and nasal

potent, direct-acting alpha-adrenergic agonist with virtually no beta-adrenergic activity; oral: produces systemic arterial vasoconstriction, resulting in nasal decongestion; nasal: produces local vasoconstriction resulting in nasal decongestion

21

Pramoxine

anesthetic that decreases the neuronal membrane’s permeability to sodium ions. Both initiation and conduction of nerve impulses are blocked; thus depolarization of the neuron is inhibited

22

Pseudoephedrine

Stimulates alpha-adrenergic receptors of respiratory mucosa causing vasoconstriction and stimulates beta-adrenergic receptors causing bronchial relaxation

23

Pyrethrins

affects neuronal membranes of lice

24

Ranitidine

competitive inhibitor of histamine H2 receptors; inhibition of gastric secretion

25

Saline nasal

Wetting solution