PHA 326: Intro to Biopharmaceutics
Finished dosage form (i.e. tablet/solution) that contains a drug substance, generally, but not necessarily in association w/ one or more ingredients
Active ingredient intended to furnish pharmacological activity / other direct effect in the diagnosis, cure, mitigation, treatment, or prevention of a disease.
Movement of the drug form the site of administration into the blood
The rate and extent to which the AI / active moiety is absorbed from a drug product and becomes available at the site of drug action
Biopharmaceutics is the science that examines the interrelationship b/w the:
- Physical and chemical properties of a drug
- Pathology and normal physiology of the patient
- Dosage form in which the drug is given
- Route by which the dosage form is administered on the bioavailability
Determining what type of effect you want a drug to have (i.e. rapid effect, prolonged effect, freq. of administration, local action) is known as _______________
What are some biopharmaceutic considerations in drug product design?
- Therapeutic objective
- Route of admin
- Dosage and regimen
- Type of product
- Manufacturing method
Does a drug have to be in solution to be absorbed?
In ________ the drug is eliminated unchanged
In __________ the drug undergoes a chemical change within the body
Following extravascular administration, ___________ must occur for a systemic effect from the drug.
Why are drug concentrations more often measured in plasma rather than whole blood/serum?
- Whole blood has other stuff in it that could affect the measurements
- Seurm still has proteins in it
- Plasma is easier to collect
Minimum effective concentration
Minimum toxic concentration
Time when therapeutic response is first observed
Time that drug remains above MEC
Related to the number of receptors with which drug interacts
What happens to Cmax, AUC, and tmax when the amount absorbed increases?
- Cmax and AUC increase
- tmax stays the same
What happens to Cmax, AUC, and tmax when the rate absorbed increases?
- Cmax and tmax increase
- AUC stays the same
How are plasma level vs. time curve parameters determined for Cmax and tmax ?
Graph data and visually pull data off graph
How are plasma level vs. time curve parameters determined for AUC?
True/False: It would be best if MEC and MTC were close together.
Area = 1/2 (a+b)*c