Liver Panel

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created 13 days ago by jessicaraya
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1

Ca

Lab Levels: 8.5-10.5

Function: Membrane Stabilizer, Helps muscles contract, cardiac function. nueral transmission, blood clotting

  • CA resoivor in teeth and bones
  • when levels are low Parathyroid hormone secreted to increase Ca
  • Ca and Albumin bind together, have a direct relationship
  • Large blood transfusion can decrease Ca bc citrate additives on blood

Measures: Ca in the blood

Low

  • Hypoparathyroid Hormone
  • Vit D deficiency/Rickets
    • Vit D works with PTH to increase Ca
  • Hypoalbuminemia
  • Pancreatitis
    • pancreatitis is associated with saponification (fats binding to Ca) of peripancreatic tissue, so reduces Ca in blood
  • Renal failure

High

  • Bone destruction
  • Antacids with Ca
  • Hyperparathyroid
2

Total Protein

Lab Level: 6.4-8.3

Albumin and Globulin measure together

Function: Albumin made in liver, helps transport drugs, enzymes, and hormones. Maintains colloidal pressure

Measure: Measure liver function and nutrition

Low

  • Malnutrition
  • Proteins loosing diseases (Nephrotic Syndrome (lost through kidneys), Chrohns disease (lost through intestines)
  • Overhydration
  • Inflammatory disease

High

  • Dehydration
3

Aspartate Aminotransferase (AST)

Lab Level 0-35 units/L

Function: enzyme is found in heart, liver, kidneys, pancreas, RBCs, skeletal muscle-> when injury occurs -> cells lyse-> release AST into blood

Measures: to indicate hepatocellular disease

Low

  • Diabetic Ketoacidosis
  • Acute/Chronic Renal Failure

High

  • Hepatic Disease/Injury
  • Skeletal Muscle Disease
  • Pancreatitis
4

Alanine Aminotransferase (ALT)

Lab Levels: 4-36 units/L

Function: found in liver, kidney, heart, skeletal muscle. ALT functions to convert alanine into pyruvate for cellular energy production

Measures: identify hepatocellular disease of liver

High

  • Hepatic Disease/Injury (Cirrhosis, Hepatitis, Jaundice)
  • Skeletal Muscle Disease
  • Pancreatitis
  • Shock
5

Lactic Dehydrogenase (LDH)

Lab level: 100-190 units/L

Function: found in heart(LDH -1), liver (LDH-5), RBCs, kidney (LDH-4), skeletal muscle, brain and lungs (LDH-3)

Measures: Injury to liver, etc.

6

Phosphate

Lab Level: 3.0-4.5 mg/dL

Ca and phosphate have an inverse relationship

Function: Absorbed in small bowel. Function for activating vitamins, enzymes, forming ATP for energy, assist in cell growth and metabolism.

Low

  • High PTH, Ca
  • Chronic Antacid Ingestion: antacids bind to phosphate in intestine
  • Alkalosis: Phos acts as a buffer, moves into cells

High

  • Low PTH/Ca
  • Acidosis: Phos driven out of the cell
  • Renal Failure: Phosphate excretion decreased
7

ALP

Lab Levels: 30-130 units/L

Function: found in liver, and bone, bilary tract, epithelium. Enzyme is excreted in bile.

8

Bili

Lab Levels: 0.3-1.0