used to describe viral RNA genome that CANNOT be immediately translated into protein
negative sense
single stranded RNA genomes that are ready for immediate translation into proteins are _____ RNA
positive-sense
process that occurs during or after penetration when viruses lose their capsid *or envelope if they have one
uncoating
phage that is a bacteriophage that incorporates itself into the host genome as a lysogenic prophage
temperate phage
viruses that can infect only certain tissues are described as having a tissue specificity OR
tropism
three main criteria used to classify viruses
- genetic makeup
- chemical composition
- structure
describes physical rupture of cell
lysis
when cells are infected but cells are not immediately lysed
persistent infection
when individual viral gees exist on separate pieces of genomic RNA, the genome is_____
segmented
multinucleated mass of cells caused by viral infection
syncytium
total nucleic acid content of a virus can be referred to as
viral genome
similarities of temperate and lytic phages
- adsorption
- penetration
- assembly
- release
- biosynthesis of viral components
complete set of viruses that are associated with the human body
human virome
methods that a virus can use to gain entry into an animal cell
- fusion of the viral envelope and the cell membrane
- engulfment/phagocytosis of the virus
persistence of bacteriophage DNA within a host chromosome
lysogeny
bacterium acquires a new trait from its temperate phage
lysogenic conversion
noncellular infectious agent that depends on other viruses for replication
satellite virus
infectious agent made up of only protein and associated with spongiform encephalopathies
prion
3 purposes of viral cultivation
- identify viruses in clinical specimens
- study the effects on host cells
- prepare vaccines
disease characterized b brain tissue pathology due to prions
spongiform encephalopathy
virus that synthesizes DNA directly from RNA using reverse transcripticase
retrovirus
describes the phage DNA that is latently incorporated into the bacterial host genome
prophage
type of virus that parasitizes other viruses infecting the same host cell
virophage
two in vivo methods for viral cultivation
- inoculating mice with viruses
- inoculating chicken eggs with viruses
enzyme capable of taking an RNA genome and generating a DNA copy is called
reverse transcriptase
process in which a virus is engulfed by a cell and enclosed in a vacuole or vesicle
endocytosis
treating viral diseases....
- antibiotics are not effective against viruses
- most vaccines target viral diseases
clear area where virus-infected monolayers of cells have been disrupted or destroyed
plaque
infectious aged that lacks a capsid and only consists of a strand of RNA
viroid
an animal virus which has intergrated its DNA into the DNA of its host cell
provirus
mass of viruses or damaged organelles caused by viral infection of a cell
inclusion body
phage type that can incorporate itself into the host genome as a lysogenic prophage
temperate phage
ways that enveloped animal viruses are released from the host cell
- bud off the cell membrane
- release from the endoplasmic reticulum
viral capsid proteins are synthesized during the ___ stage of the synthesis phase of the viral life cycle
late phase
viruses can cause cancer by
- introducing oncogenes to a host cell
- causing a loss of growth regulation
cultured cells grow in the form of ___, a single confluent sheet of cells that supports viral multiplication
monolayer
capsomeres are composed of
proteins
most host cell receptors that viruses attach to are ___ that cells use in normal function
glycoproteins
two noncellular infectious agents that are medically important are
- prions
- viroids
cellular organisms that viruses can infect
- bacteria
- fungi
- animals
- protozoa
- plants
challenging for scientists to design antiviral drugs because
viruses use host features for their life cycle so many drugs would affect the host cells
helical capsid
have rod-shaped capsomers
icosahedral capsid
arranged as a multifaceted polygon
virus types released from host cells by lysis
- naked
- complex
exocytosis or___ of enveloped viruses occurs from the host cell membrane during the release stage of viral multiplication
budding
virus that specifically infects bacteria
bacteriophage
phage DNA that is latently incorporated into the bacterial host genome is called
prophage
segmented RNA genome
individual genes exist on separate pieces of RNA
identify all the types of nucleic acid genomes which have been discovered carried by various bacteriophages
- ssDNA
- ssRNA
- dsDNA
infectious agent made up of only protein
prion
viruses were discovered by
using a filter
viruses CANNOT
- replicate outside of a cell
- consume food
clear area where a virus-infected cell lysed and infected all the neighboring cells and lysed those too
plaque
pathways that could produce proteins used by viruses
- host DNA---->mRNA---->proteins used by viruses
- viral positive-ssRNA---->proteins used by viruses
persistence of bacteriophage DNA within a host chromosome
lysogeny
most human viral infections are
self limiting
when bacteriophages infect pathogenic bacteria and result in a new pathogenic trait it is called
lysogenic conversion
cell culture is the same as
tissue culture
single confluent sheet of cells that support viral multiplication and grow cultured cells
monolayer
virus types released from host cells by lysis
- naked
- complex
integrated its DNA into the DNA of its host cell
provirus
T-even bacteriophage nucleic acid enters the host cell by
injection
capsids of naked helical viruses are
rigid and tight
capsids of enveloped helical viruses are
flexible and loose
viroids are composed of only
RNA
most RNA viruses will assemble the vision within the host cells...
cytoplasm
antiviral drugs target
one of the steps in the viral life cycle
process of ___ a prophage is activated and enters the lytic cycle
induction
in enveloped viruses, viral spike proteins insert into the host cell membrane in order to be incorporated into the new virion
assembly
viral DNA polymerase genes are expressed during the ___ of the synthesis phase
early stage
most bacteriophages have ____ DNA genomes
double stranded and have dsDNA