Ch23- O & CO2 Transport

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1

Oxygen Transport

1.5% dissolve in plasma
98.5% chemically attached to hemoglobin
Binding-buffer- takes O2 out of solution preventing equilibrium

2

Binding

buffer

3

Amount O2 bound to Hemoglobin

280 million Hb per RBC

4

O2-Hemoglobin dissociation curve

realtes saturation to partial pressure, O2 binding help

5

Lowest P02 location

P02 expected at systemic capillaries

6

Effects on Hemoglobin

pH: drop in pH facilitates unloading

Temperature: increase in temp, facilitates unloading

7

What kind of blood release 02 more easily?

warmed blood

8

Bohr effect

carbonic acid , Increasing concentration of H+ and CO2, reducing hemoglobin's affinity for oxygen, causing oxygen to release to necessary regions

9

BPG

hemoglobin molecule that helps to unload 02 molecules

10

Maternal hemoglobin

60%

11

Fetal hemaglobin

80%

12

Anemic Hypoxia

too few RBC or Hb

13

Ischemic Hypoxia

impaired/blocked circualtion

14

Histotoxic Hypoxia

metabolic poisons0 inability to use 02

15

Hypoxemia

ventilation issues

16

CO Transport

dissolved in plasma 7-10%
chemically bound to Hb ~205
Converted to carbonic acid ~70%

17

Haldane Effect

less 02 on Hb, more fully C02 can load

18

C02 & pH

carbonic acid-bicarbonate buffer system
-High H+ ion (acidic) concentrations are taken up by HC03-
-Lower H+ (basic) concentrations = release from H2C03

19

point study

higher temp, lower pH