Chap 17 Study Guide

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1

What is hemostasis? What are the three phases of hemostasis?

  • Fast series of reactions for stoppage of blood
  • Vascular Spasm
  • Platelet plug formation
  • Coagulation
2

What is vascular spasm?

  • Vasoconstriction of damaged blood vessel
3

Conversion of prothrombin into the enzyme thrombin requires?

  • Prothrombin Activator
4

Which sequence is correct for the following events?

  1. prothrombin → thrombin
  2. fibrinogen → fibrin
  3. clot retraction
  4. formation of thromboplastin

2,3,4,1

5

What is fibrinolysis?

  • Dissolving of clots
6

What enzyme can digest fibrin and dissolve a clot?

Plasmin

7

What is coagulation?

  • A set of reactions where blood is turned from a liquid to a gel.
8

What conditions impair coagulation?

  • Vitamin K deficiency
  • Severe Hypocalcemia
  • Liver disease
9

What are thromboembolic disorders? What are thrombus and embolus?

  • Thrombocytopenia: Undesirable Dot formation.
  • Thrombus: Clot that develops and persists in an unbroken blood vessel, Many lead to tissue death
  • Embolus: A thrombus freely floating in the blood stream, Can cause strokes
10

Learn the examples of the bleeding disorders covered in this chapter.

  • Thrombocytopenia: Deficient number of circulating proteins (Platelets↓ < 50,000 mm3)
  • Impaired liver function: Inability to synthesize procoagulants can also prevent the liver from producing bile, Impairing fat and Vitamin K absorption
  • Hemopilias: Include Vitamin K, Hepatitis, cirrhosis; Deficiency of procoagulants ( Factor VIII, IX, XI)