Chap 17 Study Guide
What is hemostasis? What are the three phases of hemostasis?
- Fast series of reactions for stoppage of blood
- Vascular Spasm
- Platelet plug formation
What is vascular spasm?
- Vasoconstriction of damaged blood vessel
Conversion of prothrombin into the enzyme thrombin requires?
- Prothrombin Activator
Which sequence is correct for the following events?
- prothrombin → thrombin
- fibrinogen → fibrin
- clot retraction
- formation of thromboplastin
What is fibrinolysis?
- Dissolving of clots
What enzyme can digest fibrin and dissolve a clot?
What is coagulation?
- A set of reactions where blood is turned from a liquid to a gel.
What conditions impair coagulation?
- Vitamin K deficiency
- Severe Hypocalcemia
- Liver disease
What are thromboembolic disorders? What are thrombus and embolus?
- Thrombocytopenia: Undesirable Dot formation.
- Thrombus: Clot that develops and persists in an unbroken blood vessel, Many lead to tissue death
- Embolus: A thrombus freely floating in the blood stream, Can cause strokes
Learn the examples of the bleeding disorders covered in this chapter.
- Thrombocytopenia: Deficient number of circulating proteins (Platelets↓ < 50,000 mm3)
- Impaired liver function: Inability to synthesize procoagulants can also prevent the liver from producing bile, Impairing fat and Vitamin K absorption
- Hemopilias: Include Vitamin K, Hepatitis, cirrhosis; Deficiency of procoagulants ( Factor VIII, IX, XI)