Amino Acids Structure and Function
Polar Amino Acids (Hydrophilic) and Non-Polar Amino Acids (Hydrophobic)
2 Major Classifications of Amino Acids
Where must large side chains be located when folding?
What can two cysteine molecules form? This can be in the same polypeptide or in a different polypeptide.
Holds proteins together like super glue.
What kind of bonds do charged amino acids establish with each other during protein folding or interaction?
All charged proteins are ____________?
What type of molecule is H3N+?
What type of molecule is H2N?
What is the physiological pH?
All amino acids in body are what type of stereoisomer?
What makes the primary protein structure stiff?
Higher Order Structures
The characteristics of the amino acid side groups determine what?
Interactions between the amine and carbonyl group on the peptide chain.
What are located below or above the beta-sheet?
How the secondary structures interact. Polar-non-polar side chains group together. Allows domains to be made. Membrane proteins have hydrophobic regions. A lot of side group interactions. Forces non-polar amino acids to the center.
What protein forces non-polar amino acids to the center.
Multiple peptide chains interacting together to make one molecule.
2 peptide chains?
4 peptide chains?
5+ peptide chains?
Have exact same amino acid sequence but different folding. Multiple beta-sheets in the disease form.
What other disease also has protein aggregation?
Creutzfeldt jacobs and Mad Cow Disease
What are examples of prion disease?
Beta-sheets and alpha-helices
Important to protein structure and function.
Domains (active/binding sites)
Where the action occurs. Sites that interact with other molecules.
Change in structure (prions/mutations)
Affect the outcome of the protein?