Phosholipases, Eicosanoic Acids, Sphingolipids

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created 8 years ago by chemistry_goo
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1

Which phospholipase in isvolved in metabolic regulation/cell signaling?

PLC : PIP3---> DAG and IP3

2

Arachidonic acid is the precursor to eicosanoid synthesis. It is made from what essential fatty acid?

PLA2: Linoleic Acid--> Arachidonic acid

3

Anti-inflammatory steroids (glucocorticoids) act to repress the expression of 2 enzymes involved in eicosanoid synthesis...

PLA2:
Linoleic Acid--> Arachidonic acid

COX2:
Arachidonic acid--> Prostaglandins (c20 5-member ring)

4

What is the major difference of COX1 and COX2 activity

COX1 is constituitive and used for maintenance fxn
COX2 is inducible in response to inflammation

5

What is one mode of action of aspirin

Acetylation of serine residue on cyclooxygenase enzyme

6

What is difference between structure of prostoglandin and thromboxane?

Prostaglandin: 5 membered ring
Thromboxane: 6 membered ring with O atom

7

Singulair blocks...

Leukotriene receptors

8

What are the major precursors to Ceramide synthesis?
Ceramide is utilized in synthesis of...

Serine + Palmityl Coa
Sphingolipids

9

Cermide + PC-->

Sphingomyelin

10

Ceramide+ UDP-sugar-->

Cerebroside

11

Cerebroside+ PAPS-->

Sulfatide

12

Glycocerebroside + CMP-Sialic acid-->

Ganglioside

13

Sialic acid is a derivative of..

Ceramide

14

Catabolism of Sphingolipids occurs in..

Lysosomes

15

Tay-Sachs, Gaucher's, Niemann-Pick's are diseases due to deficiency of enzyme that degrades sphingolipids
Which leads to accumulation of sphingomyelin?

Nieman Pick's

16

Which leads to accumulation of cerebrosides?

Gaucher's

17

Which leads to accumulation of gangliosides?

Tay Sach's