Phosholipases, Eicosanoic Acids, Sphingolipids
Which phospholipase in isvolved in metabolic regulation/cell signaling?
PLC : PIP3---> DAG and IP3
Arachidonic acid is the precursor to eicosanoid synthesis. It is made from what essential fatty acid?
PLA2: Linoleic Acid--> Arachidonic acid
Anti-inflammatory steroids (glucocorticoids) act to repress the expression of 2 enzymes involved in eicosanoid synthesis...
Linoleic Acid--> Arachidonic acid
Arachidonic acid--> Prostaglandins (c20 5-member ring)
What is the major difference of COX1 and COX2 activity
COX1 is constituitive and used for maintenance fxn
COX2 is inducible in response to inflammation
What is one mode of action of aspirin
Acetylation of serine residue on cyclooxygenase enzyme
What is difference between structure of prostoglandin and thromboxane?
Prostaglandin: 5 membered ring
Thromboxane: 6 membered ring with O atom
What are the major precursors to Ceramide synthesis?
Ceramide is utilized in synthesis of...
Serine + Palmityl Coa
Cermide + PC-->
Glycocerebroside + CMP-Sialic acid-->
Sialic acid is a derivative of..
Catabolism of Sphingolipids occurs in..
Tay-Sachs, Gaucher's, Niemann-Pick's are diseases due to deficiency of enzyme that degrades sphingolipids
Which leads to accumulation of sphingomyelin?
Which leads to accumulation of cerebrosides?
Which leads to accumulation of gangliosides?