adrenergic agonists and antagonists; cholinergic agonists and antagonists

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Pharmacology
Chapters 15, 16
updated 8 months ago by Akosua_Ruby
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pharmacology
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1

adrenergic agonist drugs stimulate what system? what is the primary neurotransmitter

  • stimulate the SNS (fight or flight)
  • norepinephrine
2

define catecholamines. what response can it produce?

they are chemical structure of a substance that can produce a sympathomimetic response

3

sympathomimethic: adrenergic agonist

  • what is the MOA of epinephrine?

acts on alpha1, beta1 and 2 receptors causing vasoconstriction

4

what is epinephrine used for

anaphylaxis reaction, bronchospasm, cardiac arrest, cardiac resuscitation

5

the nurse know epinephrine is working when ____

BP goes up and the patient can easily breathe

6

what are some S/S you will see if a patient is having a SE/AR to epinephrine

tachycardia, HTN, tissue death, agitation

7

what beta-adrenergic agonist works on the lungs to dilate and relax muscles?

albuterol. it relaxes bronchial smooth muscle, causing bronchodilation

8

uses of albuterol

asthma and prophlaxis for bronchospasm

9

what are some SE of albuterol?

tremors, dizziness, tachycardia, HTN, dysrhythmias

10

central-acting alpha agonist

  • clonidine MOA and use?
  • produce vasodilation
  • HTN
11

what are some SE/AR of taking clonidine

headache, drowsiness, ejaculation dysfunction, elevated liver enzymes

12

drugs that block the effects of adrenergic neurotransmitters are______. what do they block?

adrenergic antagonist or adrenergic blockers. they either block alpha or beta receptors

13

your patient is experiencing tachycardia, HTN, urinary retention, etc. what type of drug will you give?

an adrenergic antagonist

14

effects of adrenergic blockers on receptors

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15

beta 1-adrenergic blockers

  • MOA of atenolol. what does it suppress?
  • blocks beta1 adrenergic receptor sites.
  • it suppresses the RAAS system
16

atenolol is used for______

HTN, angina, and AMI

17

what should the nurse monitor closely after administering atenolol?

BP and pulse.

18

what are some SE/AR a patient will experience while taking atenolol

drowsiness, dizziness, erectile dysfunction, hypotension, bronchospasm

19

cholinergic agonist are drugs that______

what do they mimic?

  • stimulate the parasympathetic nervous system
  • mimic the action of acetylcholine
20

cholinergic: parasympathomimetic

  • bethanechol chloride stimulates_____

the cholinergic receptors

21

bethanechol chloride is used for____

to increase urinary in urinary retention and neurogenic bladder

22

what are the SE/AR of taking bethanechol

tachycardia, weakness, bronchospasm, cholinergic crisis

23

cholinergic crisis is the overstimulation of what? what will a patient in a cholinergic crisis experience?

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  • overstimulation of cholinergic system.
  • bronchospasm, tachycardia, weakness.
24

cholinergic antagonists inhibit the actions of____by blocking_____

acetylcholine; the receptors

25

cholinergic antagonists have effects on what body systems?

  • heart
  • respiratory tract
  • GI tract
  • urinary system
  • eyes
  • exocrine glands
26

what anticholinergic or parasympatholytic drug inhibits acetylcholine by occupying the receptors

atropine

27

what is atropine used for

pre-op medication to reduce salivation, increase HR, dilate pupils

28

SE/AR of atropine

tachycardia, pulmonary edema, laryngospasm, anticholinergic toxicity

29

atropine is contraindicated in______

renal and hepatic disorder, COPD, heart failure

30

the nurse know her patient is going through an anticholinergic toxicity when____

card image
31

anticholinergic agents

  • benztropine MOA
  • USE
  • AE
  • block cholinergic receptors, dopamine uptake
  • decrease involuntary symptoms of Parkinsonism
  • tachycardia, urinary retention, hallucinations, paresthesia
32

anticholinergic agen

  • tolterodine tartrate MOA
  • USE
  • AE
  • blocks cholinergic receptors in urinary bladder
  • decrease urinary frequency, urgency, incontinence
  • chest pain, tachycardia, peripheral edema, blurred vision, confusion