Circulatory Shock
any condition in which blood vessels are inadequately filled and blood can't circulate normally. Severs conditions can cause tissue death/organ failure
Hypovolemic shock
due to severe blood loss (hemorrhage, burns, sever vomitin/diarrhea).
-decrease in blood volume = increased, thready Heart rate.
-Intense vasocontriction = shifts blood from reservoirs to major circulatory ch
-B/P stable but then drops sharply
Vascular shock
blood volume is normal but circulation is poor resulting from abnormal expansion of the vascular bed caused by extreme vasodilation. Drop in peripheral resistance = rapid drop in B/P
-caused by anaphylactic shock; failure of ANS regulation (Septic shock); sun (heat) shock
Cardiogenic shock
(pump failure); heart is inefficient and can't sustain adequate circulation due to myocardial damage.
Blood draining from the myocardium
is collected by the cardiac veins and reenters the right atrium vis the coronary sinus
Deep Veins
parallel the course of systemic arteries. Naming of veins is identical to their companion arteries
Superficial Veins
run beneath the skin. Can be seen in limbs, face, & neck
- There are NO superficial arteries; therefore, names of superficial veins don't correspond to any arteries
Dural Sinuses
venous blood draining from the brain enters here rather than veins
Hepatic portal circulation
venous blood draining from digestive organs enters here and perfuses through the liver BEFORE entering systemic circulation again.
- vein-capillary-vein system
Blood pressure changes with age
Newborn: arterial pressure = 90/55
childhood (rises) to adulthood = 120/80
Old age (norm) = 150/90
What effects do atherosclerosis have on a vessel?
increase resistance due to rigidity and protein buildup
Are the vessels of males or females more affected by atherosclerosis and why?
Females: puberty to ~45, women have less atherosclerosis due to protection of estrogen
- estrogen reduces resistance due to the enhanced nitric oxide production, inhibiting endothelial release & block voltage-gated Ca2+
- stimulates the liver to produce enzymes that speed up catabolism of LDLs & increases production of HDLs, thus reducing atherosclerosis
Both sexes: after age of 65, atherosclerosis risk rises
Pulmonary Circulation
function: only brings blood into close contact w/ alveoli sofas can be exchanged.
blood: oxygen-poor, dark red blood
pulmonary circulation route
enters the R Ventricle > large pulmonary trunk > R & L pulmonary arteries > (in lungs) blood subdivides into lobar arteries > arterioles > pulmonary capillaries embedded in the air sacs
- O2 moves from alveolar sacs into blood & CO2 swaps
Pulmonary circulation route post gas exchange
Bright red blood in capillaries drain--> venules --> (form) 2 pulmonary veins exiting from each lung (2 each) > O2 rich blood is dumped into R Atrium
Pulmonary Arteries
carry O2-poor blood, CO-rich blood
Pulmonary veins
Carry O2-Rich blood, CO2-poor blood
Systemic circulation arteries
carry O2-rich blood
Systemic circulation veins
carry CO2-rich, and O2-poor blood
Systemic circulation
Function: provides functional blood supply to all body tissues. Delivers O2, nutrients, and carries away wastes & CO2
Systemic circulation route
oxygenated blood returning from pulmonary circuit is pumped OUT of L ventricle > aorta > aortic branches > arterioles > capillaries (organs)
Systemic circulation route
Venous blood draining from organs inferior to the diaphragm enter the Inferior vena cava. The vena cava dump CO2 laden blood into the R Atrium
Systemic circulation route
Venous blood draining from organs superior to the diaphragm enter the Superior vena cava. The vena cava dump CO2 laden blood into the R Atrium
Blood passes from the systemic veins to systemic arteries ...
ONLY after first moving through the pulmonary circuit
Although the entire cardiac output of the R ventricle passes through the pulmonary circulation...
a small fraction of the output of the L ventricle flow through any single organ
Aorta
- largest artery in the body & issues from L ventricle
- internal diameter is 2.5 cm
- wall is 2 MM thick; decreases slightly in size at terminus
- Aortic sinus = Opposite each aortic valve cusp; contains baroreceptors important in reflex regulation of B/P
Ascending aorta
- runs posteriorly and to Right of pulmonary trunk
- ~5 cm long before curving the left as the Aortic arch
Right and left coronary arteries
- the only branches of the ascending aorta
- supply the myocardium
Aortic arch
- is deep to the sternum
- begins and ends at the sternal angle (T4 level)
- has 3 major branches that supply the head, neck & upper limbs
Aortic arch: Brachiocephalic trunk (1)
- "armhead"
- passes superiorly under the right
clavicle and branches under the right clavicle and branches into
- Right common carotid artery
- Right subclavian artery
Aortic arch: branches 2 & 3
- Left common Carotid artery (2)
- Left subclavian artery (3)
- these 3 vessels provide blood supply to head, neck, upper limbs & thorax wall.
Descending (thoracic) aorta
- runs along anterior spine of T5 - T12
- various small arteries run off from here into viscera
Abdominal Aorta
- stems from descending aorta
- supplies abdominal walls & viscera
- ends at the T4 level
Right and left common iliac
- splits off from end of abdominal aorta
- supply the pelvic and lower limbs
Common carotid arteries
- each common carotid artery divides into 2 branches
- at the division point, each internal carotid artery has a slight dilation point => carotid sinus
- ascend through the lateral neck, at the superior border of the larynx; branches off
Carotid Sinus
contains baroreceptors that assist in flex blood pressure control
Carotid Bodies
chemoreceptors are located here and are involved in the control of respiratory rate
Right common carotid artery
- arises from the brachiocephalic trunk
Left common carotid artery
- its the second brach of the aortic arch
External Carotid Arteries
- supply cranial tissue EXCEPT for the brain and orbit
Superior thryoid artery
- branches off from external carotid into thyroid gland and larynx
Linguinal artery
- branches off from external carotid artery and supplies the tongue
Facial Artery
- branches off from external carotid artery
- supplies the skin & muscles of the anterior face
Occipital Artery
- branches off from external carotid artery
- supplies the posterior scalp
Superficial temporal Artery
- splits off from the ends of the external carotid artery
- supplies the parotid salivary gland and most of the scalp
Maxillary Artery
- supplies the upper and lower jaws, chewing muscles, teeth and nasal cavity
Middle meningeal Artery
- enters the skull through the foramen spinosum
- supplies the inner surface of the parietal bones, squamous region of temporal bones, and underlying dura mater
Internal Carotid Artery
- supplies the orbits & 80% of the cerebrum
- inside
cranium, it divides into
- ophthalmic artery
- anterior & middle cerebral artery
Ophthalmic artery
- supplies the eyes, orbits, forehead, and nose
Anterior cerebral artery
- supplies the medial surface of the frontal and parietal lobes of the cerebral hemispheres
Middle Cerebral Arteries
- run in the lateral sulci of respective cerebral hemispheres
- supply the lateral parts of the temporal, parietal and frontal lobes
Vertebral arteries
- spring from the subclavian arteries at the root of the neck and ascend through the foramina in the transverse processes of the cervical vertebrae to enter the skull through the foramen magnum
Basilar artery
- ascends along anterior aspect of the brain stem
- gives off branches to the cerebellum, pons, and inner ear
Posterior cerebral arteries
- Supply the occipital lobes & inferior parts of temporal bones
Posterior communicating arteries
- arterial shunts that connect the posterior cerebral arteries to the middle cerebral arteries anteriorly
Cerebral arterial circle (circle of Willis)
- arterial anastomoses created by the anterior and 2 posterior communicating arteries
- structure encircles the pituitary gland & optic chiasma
- unites the brain's anterior & posterior blood supplies
- equalizes BP & provides alternate blood routes (IF blockage present)
Thryocervical trunk
- short vessel that arises from subclavian artery
- supplies the thyroid gland, portions of cervical vertebrae, & spinal cord, some scapular muscles
Costocervical Trunk
- short vessel that arises from subclavian artery
- serves the deep neck & superior intercostal muscles
Subclavian Arteries
- branch to entirely supply the upper limbs
Axillary Artery
- branching from subclavian artery; runs through axilla
- gives off branches to axilla, chest wall, & shoulder girdle
Thoracoacromial artery
- supplies the deltoid muscle and pectoral region
Lateral Thoracic artery
- serves the lateral chest wall and breast
Subscapular artery
- scapula
- dorsal thorax wall
- part of latissimus dorsi muscle
Anterior & Posterior circumflex humeral arteries
- wrap around the humeral neck
- supply the shoulder joint & deltoid muscle
Brachial artery
- emerges from the axillary artery
- runs down medial aspect of humerus
- supplies the anterior flexor muscles of arm
Deep Artery of the Arm
- major branch of brachial artery
- supplies serves posterior triceps brachii muscle
Radial Artery
- runs from the median line of the cubital fossa to the styloid process of the radius
- supplies lateral muscles of forearm, wrist, thumb & index finger
- find radial pulse here
Ulnar artery
- supplies the medial aspect of the forearm, fingers 3-5, medial aspect of index finger
Common interosseous artery
- short brach at proximal end
- runs between the radius and ulna to serve the deep flexors & extensors of the forearm
Palmar arches
- branches of radial & ulnar arteries anastomose to form the superficial & deep palmar arches
Metacarpal & digital arteries
- supply the fingers
- arise from palmar arches
Internal thoracic arteries
- "mammary arteries"
- arise from subclavian arteries
- supply blood to most of anterior thorax wall
anterior intercostal arteries
- supply the intercostal spaces anteriorly
Posterior intercostal arteries
- superior 2 pair: derive from costocervical trunk
- next 9 pairs: issue from the thoracic aorta, course around the rib cage to anastomose anteriorly with anterior intercostal arteries
Subcostal artery
- 12th rib artery: emerges from thoracic aorta
Posterior intercostal arteries
Supplies:
- posterior intercostal spaces
- deep muscles of the back
- vertebrae
- spinal cord
Superior phrenic arteries
- serve the posterior aspect of the diaphragm surface
Pericardial Arteries
- several tiny branches supply the posterior pericardium
Bronchial arteries
- 2 left and 1 right bronchial arteries supply systemic blood to the lungs, bronchi, and pleurae
Esophageal arteries
- 4-5; supply esophagus
mediastinal arteries
- many & small; serve the posterior mediastinum
Inferior phrenic arteries
- emerge from the aorta at T12, inferior to diaphragm
- serve the inferior diaphragm surface
Celiac trunk
- large and unpaired branch that divides into 3 branches
- common hepatic
- splenic
- left gastric arteries
Common hepatic artery
- gives off branches to the stomach, duodenum & pancreas
Gastroduodenal artery
- branches off of common hepatic artery
- becomes the hepatic artery proper
Hepatic artery proper
- splits into right and left branches
- branches serve the liver
Splenic Artery
- passes deep to the stomach
- sends branches to the pancreas and stomach
- terminates in branches to the spleen
Left gastric artery
- supplies part of the stomach & inferior esophagus
Right and Left gastroepiplotic artery
- branches off the gastroduodenal and splenic arteries
- Serve the greater curvature of the stomach
Right Gastric Artery
- supplies the lesser curvature of the stomach
- may arise from the common hepatic artery OR the hepatic artery proper
Superior Mesenteric artery
- large, unpaired artery arises from the abdominal aorta at the L1 level immediately below the celiac trunk
- runs deep to the pancreas, enters the mesentery
Intestinal Arteries
- anastomoses from the superior mesenteric artery
- serves all of the small intestine
- serves most of the large intestine (appendix, cecum, ascending colon)
Ileocolic artery
- a part of the intestinal artery
- serves appendix, cecum, and ascending colon
Right and middle colic arteries
- is a part of the intestinal artery
- serves part of the transverse colon
Suprarenal arteries
- supply blood to the adrenal glands overlying the kidneys
Renal Arteries
- short, wide; right and left, issue from the lateral surfaces of the atria slightly below the superior mesenteric artery
- serves the kidneys
Gonadal arteries: Testicular
- paired & long; descend through the pelvis and inguinal canal to enter the scrotal sac
- serve the testes
Gonadal arteries: Ovarian
- extend into the pelvis to serve the ovaries and part of the uterine tubes
Inferior mesenteric artery
- final major branch of the abdominal aorta
- unpaired & aries from anterior aortic surface at the L3 level
- serves the distal part of large intestine
Lumbar Arteries
- four pairs of lumbar arteries arise from posterolateral surface of aorta in the lumbar region
- supplies the posterior abdominal wall
Median sacral artery
- unpaired and issues from posterior surface of abdominal aorta at the terminus
- supplies the sacrum and coccyx
Common Iliac arteries
- at L4 level; splits into Right & Left common iliac arteries
- supply lower abdominal wall, pelvic organs and lower limbs
- divides into 2 branches
Internal Iliac arteries
- paired arteries run into the pelvis
- supply blood to
pelvic walls & viscera
- bladder, rectum, uterus, & vagina
- prostate gland & ductus deferens in males
Superior and Inferior gluteal arteries
- serve the gluteal muscles
Obturator artery
- serve the adductor muscles of the medial thigh
Pudendal artery
- serve the external genitalia and perineum
External Iliac Arteries
- supply the lower limbs
- as they course through the pelvis, they give off branches to the anterior abdominal wall
Deep Femoral artery
- largest of the femoral arteries branch
- main supply to
thigh muscles
- hamstrings
- quads
- adductors
Lateral & medial circumflex femoral arteries
- encircle the neck of the femur
- Medial: supplies head & neck of femur
- Lateral: supplies the vests lateralis muscle
Popliteal Artery
- Supplies the knee region
- splits into anterior and posterior tibial arteries in leg
Anterior Tibial artery
- runs through anterior compartment of the leg
- supplies the extensor muscles
Dorsalis pedis artery
- supplies the ankle and dorsum of the foot
- pulse point; strong pulse = goof blood flow to leg
Arcuate artery
- branches off from dorsallis pedis artery
- issues the
metatarsal arteries
- supplies the metatarsals of the foot
Posterior Tibial artery
- large artery; courses through posteromedial part of leg
- supplies flexor muscles
Fibular (peroneal) artery
- proximal to posterior tibial artery
- large branch
- supplies the lateral fibularis muscle of the leg
Lateral and medial plantar arteries
- at the ankle, the posterior tibial artery divides into these
- supplies the plantar surface of the foot
- Lateral: forms the lateral end of plantar arch
Digital arteries
- serve the toes and arise from the plantar arch
Veins of the systemic circulation
- run toward the heart
- distal veins are names first
- closest to the heart named last
Superior vena cava
- great vein receives systemic blood from all areas SUPERIOR to the diaphragm, EXCEPT heart wall
- formed by the union of the Right and Left Brachiocephalic veins
- empties INTO the RIGHT atrium
Brachiocephalic Veins
- two; each vein is formed by the union of the internal jugular & subclavian vein
Inferior vena cava
- widest blood vessel in the body
- returns blood TO the heart from all body regions BELOW the diaphragm
- abdominal aorta lies to the left
Inferior vena cava
- Distal end of inferior vena cava is formed by junction of
paired common iliac veins at L5
- travels superiorly along anterior aspect of spine
- receives venous blood draining from abdominal walls, gonads & kidneys
- enters the inferior aspects of the right atrium
Dural Sinuses
- veins of the brain drain here
- an interconnected series of enlarged chambers located between the dura mater layers
Superior and Inferior sagittal sinuses
- located in the falx cerebri, which dips down between the cerebral hemispheres
- these drain into the straight sinus posteriorly
Transverse sinus
- the superior sagittal and straight sinuses empty here
- run in shallow grooves on the internal surface of the occipital bone
Sigmoid Sinuses
- the transverse sinuses drain here
- "S-shaped"
- become the Internal jugular veins
- Leave the skull via the jugular foramen
Cavernous sinuses
- flank the sphenoid body
- receive venous blood from the ophthalmic veins
Ophthalmic veins
- supply the orbits and facial veins
- drain into the nose and upper lip area
External jugular veins
- R & L drain superficial scalp & face structures served by the external carotid arteries
- descend through the lateral neck; pass obliquely over sternocleidomastoid muscles
- empty into subclavaian vein
Vertebral Veins
- DON'T serve much of the brain
- drain the cervical vertebrae, spinal cord, & some neck muscles
- run inferiorly through transverse foramina of cervical vertebrae
- join brachiocephalic veins at root of neck
Internal Jugular Veins
- paired; receive the bulk of the blood draining from the brain
- largest of the paired veins draining from the head & neck
- arise from dural venous sinuses & exit the skull via Jugular foramina
- descend through the neck alongside the internal carotid arteries
Brachiocephalic Veins
- blood from the mammary glands and the first 2 or 3 intercostal spaces drain here
Azygos System
- drain the thoracic tissues & thorax wall
- branching nature provides a collateral circulation for draining the abdominal wall and other parts served by the inferior vena cava
Palmar venous arch
- deep and superficial
- found in the hand
- empty into the Radial & Ulnar veins of the forearm
- all unite to form the Brachial vein
Brachial Vein
- vein found in the arm
- becomes the Axillary vein as it enters the axilla
Axillary Vein
- Found in the armpit, adjacent to axillary artery
- this vein becomes the Subclavian vein at the level of the first rib
Dorsal venous arch
- the superficial venous system begins here
- it's a plexus of superficial veins in the dorm of the hand
- in the
distal forearm, the plexus drains into the
- cephalic, basilic veins, & median antebrachial vein
Cephalic vein
- bends around the radius as it travels upward
- continues up the lateral superficial aspect of the arm to the shoulder
- runs in the the groove between the deltoid and pectoralis muscles to join the axillary vein
Basilic vein
- runs along the posteromedial aspect of the forearm & crosses the elbow
- Joins the brachial vein in the axilla to make the axillary vein
Medial cubital vein
- on the anterior aspect of the elbow
- connects the basilic and cephalic veins
Median antebrachial vein
- on the forearm; lies between the radial & ulnar veins in the forearm
- terminates at the elbow by entering either the basilic or cephalic vein
Azygos vein
- located against the right side of the vertebral column
- originates in the abdomen, from the R ascending lumbar vein that drains most of the right abdominal cavity wall
- and from R posterior intercostal veins that drain the chest muscles
- at T4 level, it arches over great vessels that run to the R lung & empties into Superior vena cava
Hemiazygos vein
- vessel ascends on the left side of the vertebral column
- origin: from L ascending lumbar vein & lower posterior intercostal veins mirror the inferior portion of the azygos vein on the right
- midthorax, this vein passes in front of vertebral column & joins the azygos vein
Accessory Vein
- completes the venous drainage on the L thorax
- continuation of the hemiazygos vein
- receives blood from 4-8th posterior intercostal vein
- crosses Right to empty into azygos vein
- receives venous blood from lungs
Hepatic portal vein
- veins draining digestive viscera empty here
- transports blood into liver BEFORE entering systemic circulation via hepatic veins
Portal system
- a venous system
- veins -> capillaries (or sinusoids) -> veins
- serve specific regional tissue needs
Hepatic portal system
- carries nutrient rich blood from digestive organs to liver
- hepatocytes, in liver sinusoids, remove nutrients (metabolic functions)
- phagocytic cells in the sinusoids rid blood bacteria/debris
Lumbar veins
- drain the posterior abdominal wall
- empty into inferior vena cava and into ascending lumbar veins of azygos system of thorax
Gonadal Veins (testicular or ovarian)
- Right vein drains the ovary or testis on the R side of body and empties into the inferior vena cava
- Left vein drains into the left renal vein superiorly
Renal veins
- the R and L renal veins drain the kidneys
Suprarenal veins
- Right: drink the adrenal gland on the right; empties into inferior vena cava
- Left: drains into the left renal vain
Hepatic portal system
- series of vessels in which 2 separate capillary beds lie between the arterial supply and the venous drainage
- numerous tributaries from stomach & pancreas contribute to this system
- 1st capillary bed: in stomach, intestines, drain into hepatic portal vein
Hepatic portal vein
- second capillary bed in the liver
- short portal; begins at L2 level
Superior Mesenteric vein
- major vessel of hepatic portal vein
- drains entire small intestine, part of large intestine & stomach
Splenic Vein
- major vessel of hepatic portal vein
- collects blood from spleen, parts of stomach & pancreas
- joins superior mesenteric vent form hepatic portal vein
Inferior mesenteric vein
- drains distal portions of large intestine & rectum
- joins the splenic vein before the vessel joins the superior mesenteric vein to form hepatic portal vein
Hepatic Veins
- R & L veins carry venous blood from liver to the inferior vena cava
Cystic veins
- drain the gall bladder
- join hepatic veins
Inferior phrenic veins
- drain the inferior surface of the diaphragm
Deep Veins: Posterior Tibial Vein
- formed by the union of the medial & lateral plantar veins
- ascends deep in the calf muscle
- receives the fibular vein
Anterior Tibial vein
- it's the superior continuation of the doornails pedis vein of the foot
- unites at the knee w/ the posterior tibial vein to form the popliteal vein
Popliteal vein
- crosses the back of the knee
- as it emerges from knee, it becomes the femoral vein
Femoral Vein
- emerges from popliteal vein
- drains the deep structures of the thigh
- its becomes the external iliac vein
External Iliac Vein
- enters the pelvis
- inside the pelvis, this vein unites with the internal iliac vein = common iliac vein
Superficial veins: Great & small saphenous veins
- issue from the dorsal venous arch of foot
- anastomose frequently with each other and deep veins
Great Saphenous Vein
- longest vein in the body
- travels superiorly along the medial aspect of the leg to the thigh
- empties (from thigh) distal to the inguinal ligament
Small Saphenous vein
- runs along the lateral aspect of foot & then through the fascia of the calf muscle
- Drains the calf muscle
- at the knee, it empties into the popliteal vein