Pharmacology-Chap 1 & 2

Helpfulness: 0
Set Details Share
created 7 years ago by kspurlin
342 views
updated 7 years ago by kspurlin
Grade levels:
College: Second year
show moreless
Page to share:
Embed this setcancel
COPY
code changes based on your size selection
Size:
X
Show:
1

Blood Brain Barrier

A mechanism that creates a barrier between brain tissues and circulating blood; serves to protect the central nervous system.

2

Plasma Protein Binding

Any protein able to specifically and reversibly bind other substances, such as ions, sugars, nucleic acids, or amino acids; they are believed to function in transport.

3

Lipid Solubility

Lipid soluble substances can enter a cell by dissolving in the lipid portion of the membrane and diffusing through it. The greater the lipid solubility, the more readily a molecule will pass through the membrane, i.e., the greater will be the flux for a given concentration difference.

4

Microsomal Metabolizing System

Within the cells of the liver are a group of enzymes that specifically function tp metabolize foreign (drug) substances.

5

Enzyme Induction

An enzyme inducer is a type of drug which binds to an enzyme and increases its metabolic activity.

6

Blood Levels (Bio-availability)

It is what survives of a drug after passing through the stomach and liver.

7

Drug Distribution

The pattern of distribution of drug molecules by various tissues after the chemical enters the circulatory system. Because of differences in pH, lipid content, cell membrane functions, and other individual tissue factors, most drugs are not distributed equally in all parts of the body.

8

Drug Interaction

The pharmacological result, either desirable or undesirable, of drugs interacting with themselves or with other drugs, with endogenous chemical agents, with components of the diet, or with chemicals used in or resulting from diagnostic tests.

9

Tolerance

The capacity to endure continued subjection to something.

10

Dependence / Addiction

The state of relying on or being controlled by someone or something else.

11

Compliance

Refers to the patient taking a drug exactly as prescribed.

12

First Pass Effect

(also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism whereby the concentration of a drug is greatly reduced before it reaches the systemic circulation.

13

Entero-hepatic cycling

Refers to the circulation of biliary acids, bilirubin, drugs, or other substances from the liver to the bile, followed by entry into the small intestine, absorption by the enterocyte and transport back to the liver.

14

Site of Action

The place in the body where a drug exerts its effects.

15

Mechanism of Action (MOA)

Refers to the specific biochemical interaction through which a drug substance produces its pharmacological effect.

16

Dose / Response Curve

Dose - The amount taken.
Response Curve - A therapeutic value that has maxed out. Taking more of the same drug will not give anymore relief.

17

Therapeutic Window

(or pharmaceutical window) of a drug is the range of drug dosages which can treat disease effectively while staying within the safety range.

18

Side Effect

A peripheral or secondary effect, especially an undesirable secondary effect of a drug or therapy.

19

Adverse Effect

is a harmful and undesired effect resulting from a medication.

20

Toxic Effect

is the degree to which a substance can damage an organism.

21

Pharmacokinetics

The branch of pharmacology concerned with the movement of drugs within the body.

22

Pharmacodynamics

The branch of pharmacology concerned with the effects of drugs and the mechanism of their action.

23

Pharmacotherapeutics

The study of how drugs are used to treat disease; also called clinical pharmacology.

24

Pharmacognosy

The branch of knowledge concerned with medicinal drugs obtained from plants or other natural sources.

25

Posology

The part of medicine concerned with dosage.

26

Pharmacy

The science or practice of the preparation and dispensing of medicinal drugs.

27

Toxicology

The branch of science concerned with the nature, effects, and detection of poisons.`